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NMUR1 neuromedin U receptor 1 [ Homo sapiens (human) ]

Gene ID: 10316, updated on 16-Apr-2024

Summary

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Official Symbol
NMUR1provided by HGNC
Official Full Name
neuromedin U receptor 1provided by HGNC
Primary source
HGNC:HGNC:4518
See related
Ensembl:ENSG00000171596 MIM:604153; AllianceGenome:HGNC:4518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FM3; FM-3; GPC-R; GPR66; NMU1R; (FM-3)
Summary
Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including activation of phospholipase C activity; chloride transport; and second-messenger-mediated signaling. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 2.5), lung (RPKM 1.6) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
2q37.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (231518455..231530445, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232002894..232014900, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232387898..232395156, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 22, pseudogene Neighboring gene long intergenic non-protein coding RNA 471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232378431-232379240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232390957-232391458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232392564-232393091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232393092-232393618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232396108-232396842 Neighboring gene uncharacterized LOC105376787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232400385-232400886 Neighboring gene MPRA-validated peak4079 silencer Neighboring gene Sharpr-MPRA regulatory region 7070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17292 Neighboring gene ribosomal protein L21 pseudogene 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients. Tsukada A, et al. Int J Mol Sci, 2022 Sep 23. PMID 36232539, Free PMC Article
  2. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. Szekeres PG, et al. J Biol Chem, 2000 Jul 7. PMID 10811630
  3. Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. Tan CP, et al. Genomics, 1998 Sep 1. PMID 9782091
  4. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. Fujii R, et al. J Biol Chem, 2000 Jul 14. PMID 10783389
  5. Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Kojima M, et al. Biochem Biophys Res Commun, 2000 Sep 24. PMID 11027493

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients' nasal mucosa.
    Title: Expression of NMU and NMUR1 in tryptase-positive mast cells and PBLs in allergic rhinitis patients' nasal mucosa.
  2. Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
    Title: Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
  3. Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients.
    Title: Increased NMUR1 Expression in Mast Cells in the Synovial Membrane of Obese Osteoarthritis Patients.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuromedin U binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuromedin U receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in smooth muscle contraction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neuromedin-U receptor 1
Names
G-protein coupled receptor 66
G-protein coupled receptor FM-3
NMU-R1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006056.5 → NP_006047.3  neuromedin-U receptor 1

    See identical proteins and their annotated locations for NP_006047.3

    Status: VALIDATED

    Source sequence(s)
    AC017104, AF272362, BP198644
    Consensus CDS
    CCDS2486.1
    UniProtKB/Swiss-Prot
    O43664, Q7LDP6, Q8NE20, Q9HB89
    Related
    ENSP00000305877.4, ENST00000305141.5
    Conserved Domains (1) summary
    pfam00001
    Location:77 → 356
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    231518455..231530445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712195.4 → XP_006712258.1  neuromedin-U receptor 1 isoform X3

    UniProtKB/TrEMBL
    B4DTH8
    Conserved Domains (1) summary
    pfam00001
    Location:77 → 249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. XM_006712196.4 → XP_006712259.1  neuromedin-U receptor 1 isoform X4

    UniProtKB/TrEMBL
    B4DTH8
    Conserved Domains (1) summary
    pfam00001
    Location:77 → 249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_011510488.3 → XP_011508790.1  neuromedin-U receptor 1 isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:77 → 249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. XM_011510489.3 → XP_011508791.1  neuromedin-U receptor 1 isoform X5

    UniProtKB/TrEMBL
    B4DTH8
    Conserved Domains (1) summary
    pfam00001
    Location:77 → 249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  5. XM_011510487.4 → XP_011508789.1  neuromedin-U receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011508789.1

    UniProtKB/Swiss-Prot
    Q9HB89
    Conserved Domains (1) summary
    pfam00001
    Location:54 → 333
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    232002894..232014900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340177.1 → XP_054196152.1  neuromedin-U receptor 1 isoform X3

  2. XM_054340178.1 → XP_054196153.1  neuromedin-U receptor 1 isoform X4

  3. XM_054340176.1 → XP_054196151.1  neuromedin-U receptor 1 isoform X2

  4. XM_054340179.1 → XP_054196154.1  neuromedin-U receptor 1 isoform X5

  5. XM_054340175.1 → XP_054196150.1  neuromedin-U receptor 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HB89.1 GenPept UniProtKB/Swiss-Prot:Q9HB89

Gene LinkOut

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