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ALKBH8 alkB homolog 8, tRNA methyltransferase [ Physeter catodon (sperm whale) ]

Gene ID: 102992533, updated on 10-Mar-2024

Summary

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Gene symbol
ALKBH8
Gene description
alkB homolog 8, tRNA methyltransferase
See related
Ensembl:ENSPCTG00005005892
Gene type
protein coding
RefSeq status
MODEL
Organism
Physeter catodon
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Physeteridae; Physeter
Orthologs
human mouse all
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Genomic context

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See ALKBH8 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_04 current ASM283717v5 (GCF_002837175.3) 16 NC_041229.1 (24855321..24909655)
102 previous assembly ASM283717v2 (GCF_002837175.2) 16 NC_041229.1 (24855301..24909635)

Chromosome 16 - NC_041229.1Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 1 Neighboring gene succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial-like Neighboring gene hypoxia-inducible lipid droplet-associated protein-like Neighboring gene HIG1 domain family member 1A, mitochondrial-like Neighboring gene guanylate cyclase 1 soluble subunit alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alkylated DNA repair protein alkB homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002837175.3-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM283717v5 Primary Assembly

Genomic

  1. NC_041229.1 Reference ASM283717v5 Primary Assembly

    Range
    24855321..24909655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007123358.3 → XP_007123420.1  alkylated DNA repair protein alkB homolog 8 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9FHR1
    Related
    ENSPCTP00005008386.1, ENSPCTT00005009234.1
    Conserved Domains (4) summary
    pfam09004
    Location:44 → 80
    DUF1891; Domain of unknown function (DUF1891)
    cd12431
    Location:85 → 165
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    pfam08241
    Location:455 → 544
    Methyltransf_11; Methyltransferase domain
    cl21496
    Location:179 → 377
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  2. XM_024117386.3 → XP_023973154.1  alkylated DNA repair protein alkB homolog 8 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9SBH4
    Conserved Domains (5) summary
    pfam09004
    Location:44 → 80
    DUF1891; Domain of unknown function (DUF1891)
    cd12431
    Location:85 → 165
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    pfam13649
    Location:453 → 529
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:412 → 488
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl21496
    Location:179 → 377
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  3. XM_007123359.3 → XP_007123421.1  alkylated DNA repair protein alkB homolog 8 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9FHX7
    Conserved Domains (3) summary
    pfam08241
    Location:337 → 426
    Methyltransf_11; Methyltransferase domain
    cl17169
    Location:1 → 47
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl21496
    Location:61 → 259
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  4. XM_028501607.2 → XP_028357408.1  alkylated DNA repair protein alkB homolog 8 isoform X2

    UniProtKB/TrEMBL
    A0A455C9S9
    Conserved Domains (4) summary
    pfam09004
    Location:1 → 37
    DUF1891; Domain of unknown function (DUF1891)
    cd12431
    Location:42 → 122
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    pfam13649
    Location:410 → 497
    Methyltransf_25; Methyltransferase domain
    cl21496
    Location:136 → 334
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
Nucleotide Protein
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