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PKLR pyruvate kinase L/R [ Panthera tigris (tiger) ]

Gene ID: 102971027, updated on 10-Mar-2024

Summary

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Gene symbol
PKLR
Gene description
pyruvate kinase L/R
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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See PKLR in Genome Data Viewer
Location:
chromosome: F3
Exon count:
12
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) F3 NC_056678.1 (68245184..68252524)

Chromosome F3 - NC_056678.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC122235924 Neighboring gene RUN and SH3 domain containing 1 Neighboring gene farnesyl diphosphate synthase Neighboring gene uncharacterized LOC122235963 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 3 Neighboring gene CDC like kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056678.1 Chromosome F3 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pyruvate kinase PKLR
Names
pyruvate kinase, liver and RBC

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056678.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    68245184..68252524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042976677.1 → XP_042832611.1  pyruvate kinase PKLR isoform X2

    Conserved Domains (1) summary
    cd00288
    Location:85 → 573
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  2. XM_042976676.1 → XP_042832610.1  pyruvate kinase PKLR isoform X1

    Conserved Domains (1) summary
    cd00288
    Location:89 → 577
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
Nucleotide Protein
Heading Accession and Version

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