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DGKA diacylglycerol kinase alpha [ Panthera tigris (tiger) ]

Gene ID: 102958925, updated on 18-Sep-2024

Summary

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Gene symbol
DGKA
Gene description
diacylglycerol kinase alpha
See related
Ensembl:ENSPTIG00000017513
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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See DGKA in Genome Data Viewer
Location:
chromosome: B4
Exon count:
27
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) B4 NC_056666.1 (81703308..81725288)

Chromosome B4 - NC_056666.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase D-like Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2 Neighboring gene uncharacterized LOC122240367 Neighboring gene RAB5B, member RAS oncogene family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056666.1 Chromosome B4 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase alpha
Names
diacylglycerol kinase, alpha 80kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056666.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    81703308..81725288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007081473.3 → XP_007081535.1  diacylglycerol kinase alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C9MA78
    Related
    ENSPTIP00000019836.1
    Conserved Domains (6) summary
    smart00045
    Location:519 → 700
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:377 → 498
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:113 → 182
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:4 → 109
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:269 → 330
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:200 → 260
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  2. XM_042992494.1 → XP_042848428.1  diacylglycerol kinase alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C9MA78
    Conserved Domains (6) summary
    smart00045
    Location:519 → 700
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:377 → 498
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:113 → 182
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:4 → 109
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cd20890
    Location:269 → 330
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:200 → 260
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  3. XM_007081471.3 → XP_007081533.2  diacylglycerol kinase alpha isoform X1

    Conserved Domains (5) summary
    smart00109
    Location:249 → 295
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:563 → 744
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:421 → 542
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:157 → 226
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00040
    Location:311 → 355
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  4. XM_042992493.1 → XP_042848427.1  diacylglycerol kinase alpha isoform X2

    Conserved Domains (5) summary
    smart00109
    Location:243 → 289
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:557 → 738
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:415 → 536
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:151 → 220
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00040
    Location:305 → 349
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  5. XM_042992495.1 → XP_042848429.1  diacylglycerol kinase alpha isoform X4

    Conserved Domains (3) summary
    smart00045
    Location:273 → 454
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:131 → 252
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20890
    Location:23 → 84
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
Nucleotide Protein
Heading Accession and Version

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