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FASN fatty acid synthase [ Panthera tigris (tiger) ]

Gene ID: 102956933, updated on 10-Mar-2024

Summary

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Gene symbol
FASN
Gene description
fatty acid synthase
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera tigris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
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Genomic context

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See FASN in Genome Data Viewer
Location:
chromosome: E1
Exon count:
42
Annotation release Status Assembly Chr Location
102 current P.tigris_Pti1_mat1.1 (GCF_018350195.1) E1 NC_056673.1 (60317505..60335935, complement)

Chromosome E1 - NC_056673.1Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene coiled-coil domain containing 57 Neighboring gene solute carrier family 16 member 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056673.1 Chromosome E1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fatty acid synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Panthera tigris Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.tigris_Pti1_mat1.1 Primary Assembly

Genomic

  1. NC_056673.1 Reference P.tigris_Pti1_mat1.1 Primary Assembly

    Range
    60317505..60335935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042966039.1 → XP_042821973.1  fatty acid synthase isoform X2

    Conserved Domains (7) summary
    cd08954
    Location:1878 → 2114
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00827
    Location:497 → 788
    PKS_AT; Acyl transferase domain in polyketide synthase (PKS) enzymes
    smart00829
    Location:1566 → 1856
    PKS_ER; Enoylreductase
    PRK10252
    Location:2132 → 2327
    entF; enterobactin non-ribosomal peptide synthetase EntF
    cd00833
    Location:2 → 404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    cl00509
    Location:875 → 1010
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl21494
    Location:2245 → 2507
    Abhydrolase; alpha/beta hydrolases

  2. XM_042966038.1 → XP_042821972.1  fatty acid synthase isoform X1

    Conserved Domains (7) summary
    cd08954
    Location:2018 → 2254
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00827
    Location:637 → 928
    PKS_AT; Acyl transferase domain in polyketide synthase (PKS) enzymes
    smart00829
    Location:1706 → 1996
    PKS_ER; Enoylreductase
    PRK10252
    Location:2272 → 2467
    entF; enterobactin non-ribosomal peptide synthetase EntF
    cd00833
    Location:142 → 544
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    cl00509
    Location:1015 → 1150
    hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    cl21494
    Location:2385 → 2647
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
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