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TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough [ Homo sapiens (human) ]

Gene ID: 102800317, updated on 10-Mar-2024

Summary

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Official Symbol
TPTEP2-CSNK1Eprovided by HGNC
Official Full Name
TPTEP2-CSNK1E readthroughprovided by HGNC
Primary source
HGNC:HGNC:53829
See related
Ensembl:ENSG00000283900 AllianceGenome:HGNC:53829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOC400927-CSNK1E
Summary
This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in endometrium (RPKM 31.3), brain (RPKM 31.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
22q13.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38290691..38398915, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38754994..38863179, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38686697..38794920, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38620666-38621166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38624990-38625720 Neighboring gene transmembrane protein 184B Neighboring gene TMEM184B antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 92 Neighboring gene RNA, 7SL, cytoplasmic 704, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38659892-38660392 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38667767-38668476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38679509-38680035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685261-38685970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685971-38686678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38694325-38695524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19004 Neighboring gene casein kinase 1 epsilon Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38706687-38707466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38714878-38715782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38718279-38719070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38720450-38720962 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38720963-38721473 Neighboring gene Sharpr-MPRA regulatory region 8587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38723521-38724032 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38737560-38737744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38740513-38741012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38743105-38744002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13716 Neighboring gene TPTE pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38793649-38794432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38799517-38800018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38800019-38800518 Neighboring gene uncharacterized LOC105373030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38813561-38814060 Neighboring gene uncharacterized LOC101927183 Neighboring gene potassium inwardly rectifying channel subfamily J member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. Long AM, et al. J Med Chem, 2012 Nov 26. PMID 23106386
  2. Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Xu Y, et al. Oncogene, 2010 May 27. PMID 20305697
  3. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Daub H, et al. Mol Cell, 2008 Aug 8. PMID 18691976
  4. Large-scale proteomics analysis of the human kinome. Oppermann FS, et al. Mol Cell Proteomics, 2009 Jul. PMID 19369195, Free PMC Article
  5. Patterns of somatic mutation in human cancer genomes. Greenman C, et al. Nature, 2007 Mar 8. PMID 17344846, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CKI-epsilon is a potent TDP-43 kinase in vivo and in vitro.
    Title: TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ17345, FLJ34950

General protein information

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Preferred Names
casein kinase I isoform epsilon
Names
CKI-epsilon
LOC400927-CSNK1E readthrough
NP_001276841.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289912.2 → NP_001276841.1  casein kinase I isoform epsilon

    See identical proteins and their annotated locations for NP_001276841.1

    Status: VALIDATED

    Source sequence(s)
    AK092269, AL020993, Z97056
    UniProtKB/Swiss-Prot
    P49674
    UniProtKB/TrEMBL
    Q53EZ1, Q5U045
    Related
    ENSP00000383067.2, ENST00000400206.7
    Conserved Domains (1) summary
    cd14125
    Location:8 → 282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38290691..38398915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38754994..38863179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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