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LOC102723996 ICOS ligand [ Homo sapiens (human) ]

Gene ID: 102723996, updated on 10-Oct-2024

Summary

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Gene symbol
LOC102723996
Gene description
ICOS ligand
See related
Ensembl:ENSG00000277117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Annotation information
Note: GeneID:102723996 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:23308. [10 Jun 2021]
Expression
Ubiquitous expression in brain (RPKM 4.3), lymph node (RPKM 3.5) and 23 other tissues See more
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Genomic context

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See LOC102723996 in Genome Data Viewer
Location:
21p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (5022531..5046683)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379484 Neighboring gene DNA (cytosine-5)-methyltransferase 3-like Neighboring gene uncharacterized LOC124905052 Neighboring gene uncharacterized LOC124900468 Neighboring gene putative proline-rich protein 21 Neighboring gene uncharacterized CH507-9B2.8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000021.9 Chromosome 21 Reference GRCh38.p14 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

Genotypes

General gene information

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Homology

General protein information

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Preferred Names
ICOS ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363770.2 → NP_001350699.1  ICOS ligand precursor

    Status: VALIDATED

    Source sequence(s)
    FP565260
    UniProtKB/Swiss-Prot
    A8MUZ1, O75144, Q9HD18, Q9NRQ1
    UniProtKB/TrEMBL
    A0A8V8TQ42, A0N0L8
    Related
    ENST00000623960.4
    Conserved Domains (2) summary
    pfam07686
    Location:20 → 131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153 → 212
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    5022531..5046683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440643.1 → XP_047296599.1  ICOS ligand isoform X5

  2. XM_011546078.3 → XP_011544380.1  ICOS ligand isoform X2

    See identical proteins and their annotated locations for XP_011544380.1

    UniProtKB/TrEMBL
    A0A2R8Y5W7
    Conserved Domains (2) summary
    pfam07686
    Location:20 → 131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153 → 225
    Ig; Immunoglobulin domain

  3. XM_047440644.1 → XP_047296600.1  ICOS ligand isoform X5

  4. XM_047440646.1 → XP_047296602.1  ICOS ligand isoform X7

  5. XM_006723899.3 → XP_006723962.1  ICOS ligand isoform X1

    UniProtKB/TrEMBL
    K4DIA0
    Conserved Domains (2) summary
    pfam07686
    Location:20 → 131
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:153 → 225
    Ig; Immunoglobulin domain

  6. XM_011546079.2 → XP_011544381.1  ICOS ligand isoform X3

    See identical proteins and their annotated locations for XP_011544381.1

    UniProtKB/TrEMBL
    A0A8V8TQ42, A0A8V8TQV9
    Conserved Domains (3) summary
    cd00096
    Location:154 → 162
    Ig; Ig strand B [structural motif]
    cd20935
    Location:23 → 135
    IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
    cl11960
    Location:149 → 224
    Ig; Immunoglobulin domain

  7. XM_047440645.1 → XP_047296601.1  ICOS ligand isoform X6

  8. XM_047440647.1 → XP_047296603.1  ICOS ligand isoform X8

  9. XM_047440648.1 → XP_047296604.1  ICOS ligand isoform X8

  10. XM_047440642.1 → XP_047296598.1  ICOS ligand isoform X4

Nucleotide Protein
Heading Accession and Version

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