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SPDYE17 speedy/RINGO cell cycle regulator family member E17 [ Homo sapiens (human) ]

Gene ID: 102723849, updated on 23-Nov-2023

Summary

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Official Symbol
SPDYE17provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E17provided by HGNC
Primary source
HGNC:HGNC:51513
See related
Ensembl:ENSG00000186645 AllianceGenome:HGNC:51513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 9.5), skin (RPKM 2.8) and 23 other tissues See more
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Genomic context

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Location:
7q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (77022306..77032361, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (76566553..76576615)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76651623..76661678, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DTX2P1-UPK3BP1-PMS2P11 readthrough, transcribed pseudogene Neighboring gene DTX2 pseudogene 1 Neighboring gene farnesyl diphosphate synthase pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76612883-76613456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76628288-76629118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76629119-76629947 Neighboring gene Sharpr-MPRA regulatory region 3059 Neighboring gene uroplakin 3B pseudogene 1 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 11 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 9 Neighboring gene speedy/RINGO cell cycle regulator family member E18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76693975-76694649 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Gopinathan L, et al. Results Probl Cell Differ, 2011. PMID 21630153
  2. CDK activation by non-cyclin proteins. Nebreda AR. Curr Opin Cell Biol, 2006 Apr. PMID 16488127
  3. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Chauhan S, et al. Cell Mol Life Sci, 2012 Nov. PMID 22763696
  4. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng A, et al. Cell Cycle, 2005 Jan. PMID 15611625
  5. Characterization of a new family of cyclin-dependent kinase activators. Dinarina A, et al. Biochem J, 2005 Mar 1. PMID 15574121, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative speedy protein E17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351351.3 → NP_001338280.1  putative speedy protein E17

    Status: VALIDATED

    Source sequence(s)
    AC007000, AC114737
    Consensus CDS
    CCDS94130.1
    UniProtKB/Swiss-Prot
    A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0
    Related
    ENSP00000501236.1, ENST00000671986.3
    Conserved Domains (1) summary
    pfam11357
    Location:107 → 261
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    77022306..77032361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419719.1 → XP_047275675.1  putative speedy protein E17 isoform X1

    UniProtKB/Swiss-Prot
    A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    76566553..76576615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DUD2.1 GenPept UniProtKB/Swiss-Prot:P0DUD2

Gene LinkOut

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Molecular Biology Databases