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Xylb xylulokinase homolog (H. influenzae) [ Mus musculus (house mouse) ]

Gene ID: 102448, updated on 2-Nov-2024

Summary

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Official Symbol
Xylbprovided by MGI
Official Full Name
xylulokinase homolog (H. influenzae)provided by MGI
Primary source
MGI:MGI:2142985
See related
Ensembl:ENSMUSG00000035769 AllianceGenome:MGI:2142985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable D-xylulokinase activity. Predicted to be involved in D-glucuronate catabolic process to D-xylulose 5-phosphate and xylulose metabolic process. Predicted to be active in cytosol. Orthologous to human XYLB (xylulokinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 57.9), liver adult (RPKM 23.4) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Xylb in Genome Data Viewer
Location:
9 F3; 9 71.33 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119186447..119222863)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119357381..119393797)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11425 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene acetyl-Coenzyme A acyltransferase 1A Neighboring gene predicted gene, 53515 Neighboring gene activin receptor IIB

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. Bunker RD, et al. J Biol Chem, 2013 Jan 18. PMID 23179721, Free PMC Article
  2. An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Man JCK, et al. Nat Commun, 2019 Oct 30. PMID 31666509, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables D-xylulokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-xylulokinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables D-xylulokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in D-xylose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in xylulose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xylulose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xylulose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
xylulose kinase
NP_001028381.1
NP_001186497.1
NP_001346628.1
XP_030099799.1
XP_030099800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033209.3 → NP_001028381.1  xylulose kinase isoform 1

    See identical proteins and their annotated locations for NP_001028381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK143476, AK165759
    Consensus CDS
    CCDS23614.1
    UniProtKB/Swiss-Prot
    B2RR66, Q3TNA1, Q8R156
    UniProtKB/TrEMBL
    Q66JV3
    Related
    ENSMUSP00000047254.9, ENSMUST00000039610.10
    Conserved Domains (2) summary
    PLN02669
    Location:26 → 549
    PLN02669; xylulokinase
    cd07776
    Location:24 → 494
    FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

  2. NM_001199568.1 → NP_001186497.1  xylulose kinase isoform 2

    See identical proteins and their annotated locations for NP_001186497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, one of which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK143476, AK164186, AK165759
    UniProtKB/TrEMBL
    Q3TMS3
    Conserved Domains (1) summary
    cl17037
    Location:1 → 261
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. NM_001359699.1 → NP_001346628.1  xylulose kinase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC128702, AC166052
    UniProtKB/TrEMBL
    Q66JV3
    Conserved Domains (1) summary
    cd07776
    Location:1 → 401
    FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119186447..119222863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243939.1 → XP_030099799.1  xylulose kinase isoform X1

    UniProtKB/TrEMBL
    Q66JV3
    Conserved Domains (1) summary
    cd07776
    Location:1 → 401
    FGGY_D-XK_euk; eukaryotic D-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases

  2. XM_030243940.1 → XP_030099800.1  xylulose kinase isoform X2

    UniProtKB/TrEMBL
    Q3TMS3
    Related
    ENSMUST00000213383.2
    Conserved Domains (1) summary
    cl17037
    Location:1 → 261
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TNA1.1 GenPept UniProtKB/Swiss-Prot:Q3TNA1

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