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PLCB3 phospholipase C beta 3 [ Bubalus bubalis (water buffalo) ]

Gene ID: 102413748, updated on 10-Mar-2024

Summary

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Gene symbol
PLCB3
Gene description
phospholipase C beta 3
See related
EnsemblRapid:ENSBALG00030041716
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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See PLCB3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
31
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 5 NC_059161.1 (124046291..124062546)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 5 NC_058347.1 (122268179..122284446)

Chromosome 5 - NC_059161.1Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene BCL2 associated agonist of cell death Neighboring gene G protein-coupled receptor 137

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059161.1 Reference NDDB_SH_1 Primary Assembly

    Range
    124046291..124062546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006050880.4 → XP_006050942.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

    Related
    ENSBALP00030076781.1, ENSBALT00030115332.1
    Conserved Domains (7) summary
    cd00275
    Location:728 → 843
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:1030 → 1202
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:225 → 315
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1157 → 1168
    GBP_C; coiled coil [structural motif]
    cl14615
    Location:316 → 693
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl20817
    Location:1028 → 1188
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_025286596.3 → XP_025142381.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2

    Related
    ENSBALP00030076777.1, ENSBALT00030115321.1
    Conserved Domains (5) summary
    cd08625
    Location:316 → 693
    PI-PLCc_beta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta3
    cd13361
    Location:22 → 149
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:1028 → 1201
    PLC-beta_C; PLC-beta C terminal
    cd16210
    Location:154 → 304
    EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
    cl27705
    Location:318 → 833
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
Nucleotide Protein
Heading Accession and Version

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