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PTEN phosphatase and tensin homolog [ Bubalus bubalis (water buffalo) ]

Gene ID: 102405361, updated on 10-Mar-2024

Summary

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Gene symbol
PTEN
Gene description
phosphatase and tensin homolog
See related
EnsemblRapid:ENSBALG00030008480
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
9
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 23 NC_059179.1 (9794665..9896190)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 23 NC_058365.1 (9636213..9739802)

Chromosome 23 - NC_059179.1Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC112581626 Neighboring gene ATPase family AAA domain containing 1 Neighboring gene peptidyl-prolyl cis-trans isomerase H-like Neighboring gene uncharacterized LOC123331376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
phosphatase and tensin-like protein
NP_001277906.1
XP_006073063.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290977.1 → NP_001277906.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    See identical proteins and their annotated locations for NP_001277906.1

    Status: PROVISIONAL

    Source sequence(s)
    JQ326290
    UniProtKB/TrEMBL
    I0BWL0
    Related
    ENSBALP00030015972.1, ENSBALT00030023735.1
    Conserved Domains (2) summary
    cd14509
    Location:24 → 181
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:188 → 349
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059179.1 Reference NDDB_SH_1 Primary Assembly

    Range
    9794665..9896190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006073001.4 → XP_006073063.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    See identical proteins and their annotated locations for XP_006073063.1

    Related
    ENSBALP00030015933.1, ENSBALT00030023684.1
    Conserved Domains (2) summary
    cd14509
    Location:24 → 166
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:173 → 334
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
Nucleotide Protein
Heading Accession and Version

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