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SHMT2 serine hydroxymethyltransferase 2 [ Bubalus bubalis (water buffalo) ]

Gene ID: 102398040, updated on 10-Mar-2024

Summary

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Gene symbol
SHMT2
Gene description
serine hydroxymethyltransferase 2
See related
EnsemblRapid:ENSBALG00030004131
Gene type
protein coding
RefSeq status
MODEL
Organism
Bubalus bubalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
Orthologs
human mouse all
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Genomic context

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See SHMT2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
15
Annotation release Status Assembly Chr Location
103 current NDDB_SH_1 (GCF_019923935.1) 4 NC_059160.1 (64223408..64230569)
102 previous assembly NDDB_DH_1 (GCF_019923925.1) 4 NC_058346.1 (63639420..63646581)

Chromosome 4 - NC_059160.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 1 Neighboring gene neurexophilin 4 Neighboring gene uncharacterized LOC112584553 Neighboring gene NDUFA4 mitochondrial complex associated like 2 Neighboring gene SH3 and cysteine rich domain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to type I interferon IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRISC complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NDDB_SH_1 Primary Assembly

Genomic

  1. NC_059160.1 Reference NDDB_SH_1 Primary Assembly

    Range
    64223408..64230569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006077865.3 → XP_006077927.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006077927.1

    Related
    ENSBALP00030007577.1, ENSBALT00030011580.1
    Conserved Domains (1) summary
    PLN03226
    Location:17 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  2. XM_044941537.1 → XP_044797472.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    Related
    ENSBALP00030007582.1, ENSBALT00030011588.1
    Conserved Domains (1) summary
    PLN03226
    Location:17 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  3. XM_006077861.3 → XP_006077923.1  serine hydroxymethyltransferase, mitochondrial isoform X1

    Related
    ENSBALP00030007566.1, ENSBALT00030011562.1
    Conserved Domains (2) summary
    PLN03226
    Location:38 → 502
    PLN03226; serine hydroxymethyltransferase; Provisional
    pfam00464
    Location:49 → 448
    SHMT; Serine hydroxymethyltransferase

  4. XM_006077863.3 → XP_006077925.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006077925.1

    Conserved Domains (1) summary
    PLN03226
    Location:17 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  5. XM_006077862.3 → XP_006077924.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006077924.1

    Conserved Domains (1) summary
    PLN03226
    Location:17 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  6. XM_025283813.2 → XP_025139598.1  serine hydroxymethyltransferase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl28184
    Location:1 → 341
    PLN03226; serine hydroxymethyltransferase; Provisional
Nucleotide Protein
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