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C11orf98 chromosome 11 open reading frame 98 [ Homo sapiens (human) ]

Gene ID: 102288414, updated on 10-Mar-2024

Summary

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Official Symbol
C11orf98provided by HGNC
Official Full Name
chromosome 11 open reading frame 98provided by HGNC
Primary source
HGNC:HGNC:51238
See related
Ensembl:ENSG00000278615 AllianceGenome:HGNC:51238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf48
Summary
This gene shares three exons in common with another gene, LBH domain containing 1 (GeneID:79081), but the encoded protein uses a reading frame that is different from that of the LBH domain containing 1 gene. [provided by RefSeq, Nov 2017]
Expression
Ubiquitous expression in appendix (RPKM 22.0), lymph node (RPKM 21.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62662817..62665216, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62652235..62654634, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62430289..62432688, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62391987-62392312 Neighboring gene glucosidase II alpha subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62412284-62413091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3422 Neighboring gene integrator complex subunit 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62420185-62420944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4837 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57 Neighboring gene citrate synthase lysine methyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62437829-62438570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62438571-62439310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62439311-62440052 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of Microprotein-Protein Interactions via APEX Tagging. Chu Q, et al. Biochemistry, 2017 Jul 5. PMID 28589727, Free PMC Article
  2. Diversity of translation start sites may define increased complexity of the human short ORFeome. Oyama M, et al. Mol Cell Proteomics, 2007 Jun. PMID 17317662
  3. Observation of dually decoded regions of the human genome using ribosome profiling data. Michel AM, et al. Genome Res, 2012 Nov. PMID 22593554, Free PMC Article
  4. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Zhang H, et al. Nucleic Acids Res, 2019 Nov 4. PMID 31495888, Free PMC Article
  5. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1. Shen S, et al. Ann Rheum Dis, 2021 Sep. PMID 34039624, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
uncharacterized protein C11orf98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286086.2 → NP_001273015.1  uncharacterized protein C11orf98

    See identical proteins and their annotated locations for NP_001273015.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    BX107288, CN256679
    Consensus CDS
    CCDS73306.1
    UniProtKB/Swiss-Prot
    A0A0B4J220, E9PRG8
    Related
    ENSP00000432523.2, ENST00000524958.6
    Conserved Domains (1) summary
    pfam17719
    Location:1 → 98
    DUF5564; Family of unknown function (DUF5564)

RNA

  1. NR_104414.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BG681685, BX107288, CN256679
    Related
    ENST00000532786.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62662817..62665216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62652235..62654634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PRG8.2 GenPept UniProtKB/Swiss-Prot:E9PRG8

Gene LinkOut

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