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WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Bos mutus (wild yak) ]

Gene ID: 102278119, updated on 10-Mar-2024

Summary

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Gene symbol
WFIKKN2
Gene description
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Locus tag
M91_15582
See related
Ensembl:ENSBMUG00000019244
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos mutus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See WFIKKN2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
2
Annotation release Status Assembly Chr Location
101 current BosGru_v2.0 (GCF_000298355.1) Unplaced Scaffold NW_005393186.1 (540043..545259, complement)

NW_005393186.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 9 Neighboring gene transducer of ERBB2, 1 Neighboring gene ankyrin repeat domain-containing protein 40 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene LUC7 like 3 pre-mRNA splicing factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_005393186.1 Unplaced Scaffold Reference BosGru_v2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yak genome and adaptation to life at high altitude. Qiu Q, et al. Nat Genet, 2012 Jul 1. PMID 22751099
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
Names
WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos mutus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BosGru_v2.0 Primary Assembly

Genomic

  1. NW_005393186.1 Reference BosGru_v2.0 Primary Assembly

    Range
    540043..545259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005890275.2 → XP_005890337.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

    See identical proteins and their annotated locations for XP_005890337.1

    UniProtKB/TrEMBL
    A0A6B0RT37
    Related
    ENSBMUP00000025671.1, ENSBMUT00000029552.1
    Conserved Domains (6) summary
    cd05765
    Location:222 → 302
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:136 → 172
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:453 → 561
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam07679
    Location:208 → 302
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:383 → 434
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:42 → 88
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
Nucleotide Protein
Heading Accession and Version

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