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ZNF443 zinc finger protein 443 [ Homo sapiens (human) ]

Gene ID: 10224, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF443provided by HGNC
Official Full Name
zinc finger protein 443provided by HGNC
Primary source
HGNC:HGNC:20878
See related
Ensembl:ENSG00000180855 MIM:606697; AllianceGenome:HGNC:20878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZK1
Summary
Zinc finger proteins (ZNFs) bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. For a general description of these proteins, see ZNF91 (MIM 603971).[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in skin (RPKM 1.2), endometrium (RPKM 1.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12429706..12441021, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12558105..12569423, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12540520..12551835, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 442 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene zinc finger protein 799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14055 Neighboring gene zinc finger protein 709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12605336-12606216 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12606217-12607096 Neighboring gene MT-ND2 pseudogene 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZK1, a novel Krüppel-type zinc finger gene, is induced following exposure to ionizing radiation and enhances apoptotic cell death on hematopoietic cells. Katoh O, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731181
  2. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Lee SM, et al. Life Sci, 2002 Sep 27. PMID 12215374
  3. Analysis of BCL6-interacting proteins by tandem mass spectrometry. Miles RR, et al. Mol Cell Proteomics, 2005 Dec. PMID 16147992
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The gene expression of ZK1 was down-regulated during early apoptosis of human hepatoma cells exposed to Paeoniae Radix extract in vitro.
    Title: Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 443
Names
Kruppel-type zinc finger (C2H2)
krueppel-type zinc finger protein ZK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005815.5 → NP_005806.3  zinc finger protein 443

    Status: VALIDATED

    Source sequence(s)
    AC008758
    Consensus CDS
    CCDS32918.1
    UniProtKB/Swiss-Prot
    Q9Y2A4
    Related
    ENSP00000301547.5, ENST00000301547.10
    Conserved Domains (3) summary
    COG5048
    Location:196 → 579
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:506 → 526
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 43
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12429706..12441021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12558105..12569423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2A4.2 GenPept UniProtKB/Swiss-Prot:Q9Y2A4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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