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tjp2a tight junction protein 2a (zona occludens 2) [ Xiphophorus maculatus (southern platyfish) ]

Gene ID: 102225919, updated on 10-Mar-2024

Summary

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Gene symbol
tjp2a
Gene description
tight junction protein 2a (zona occludens 2)
See related
Ensembl:ENSXMAG00000005032
Gene type
protein coding
RefSeq status
MODEL
Organism
Xiphophorus maculatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; Xiphophorus
Also known as
tjp2
Orthologs
zebrafish all
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Genomic context

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See tjp2a in Genome Data Viewer
Location:
chromosome: 8
Exon count:
27
Annotation release Status Assembly Chr Location
102 current X_maculatus-5.0-male (GCF_002775205.1) 8 NC_036450.1 (3823849..3866697)
101 previous assembly Xiphophorus_maculatus-4.4.2 (GCF_000241075.1) Unplaced Scaffold NW_005372569.1 (342612..361862)

Chromosome 8 - NC_036450.1Genomic Context describing neighboring genes Neighboring gene nuclear factor 7, brain-like Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, beta a Neighboring gene amyloid beta (A4) precursor protein-binding, family A, member 1b Neighboring gene MAM domain containing 2 Neighboring gene solute carrier family 30 member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2
Names
tight junction protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xiphophorus maculatus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference X_maculatus-5.0-male Primary Assembly

Genomic

  1. NC_036450.1 Reference X_maculatus-5.0-male Primary Assembly

    Range
    3823849..3866697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023337866.1 → XP_023193634.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A3B5QRG0, A0A3B5QW25
    Related
    ENSXMAP00000035453.1, ENSXMAT00000032562.1
    Conserved Domains (4) summary
    smart00072
    Location:719 → 897
    GuKc; Guanylate kinase homologues
    cd00992
    Location:523 → 600
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:617 → 684
    SH3; Src Homology 3 domain superfamily
    cl25887
    Location:151 → 253
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  2. XM_023337863.1 → XP_023193631.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A3B5R5Z3
    Related
    ENSXMAP00000038644.1, ENSXMAT00000037374.1
    Conserved Domains (4) summary
    smart00072
    Location:797 → 975
    GuKc; Guanylate kinase homologues
    cd00992
    Location:601 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:695 → 762
    SH3; Src Homology 3 domain superfamily
    cl25887
    Location:229 → 331
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  3. XM_023337864.1 → XP_023193632.1  tight junction protein ZO-2 isoform X2

    UniProtKB/TrEMBL
    A0A3B5Q4X2
    Related
    ENSXMAP00000026883.1, ENSXMAT00000041547.1
    Conserved Domains (4) summary
    smart00072
    Location:797 → 975
    GuKc; Guanylate kinase homologues
    cd00992
    Location:601 → 678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:695 → 762
    SH3; Src Homology 3 domain superfamily
    cl25887
    Location:229 → 331
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  4. XM_023337865.1 → XP_023193633.1  tight junction protein ZO-2 isoform X3

    UniProtKB/TrEMBL
    A0A3B5QRG0, M3ZS72
    Related
    ENSXMAP00000005065.2, ENSXMAT00000005070.2
    Conserved Domains (4) summary
    smart00072
    Location:738 → 916
    GuKc; Guanylate kinase homologues
    cd00992
    Location:542 → 619
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17036
    Location:636 → 703
    SH3; Src Homology 3 domain superfamily
    cl25887
    Location:170 → 272
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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