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blm BLM RecQ like helicase [ Xiphophorus maculatus (southern platyfish) ]

Gene ID: 102219037, updated on 10-Mar-2024

Summary

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Gene symbol
blm
Gene description
BLM RecQ like helicase
See related
Ensembl:ENSXMAG00000002951
Gene type
protein coding
RefSeq status
MODEL
Organism
Xiphophorus maculatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; Xiphophorus
Orthologs
human zebrafish all
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Genomic context

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See blm in Genome Data Viewer
Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
102 current X_maculatus-5.0-male (GCF_002775205.1) 2 NC_036444.1 (9873961..9883971, complement)
101 previous assembly Xiphophorus_maculatus-4.4.2 (GCF_000241075.1) Unplaced Scaffold NW_005372203.1 (1334104..1343788)

Chromosome 2 - NC_036444.1Genomic Context describing neighboring genes Neighboring gene FERM domain-containing protein 5-like Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene cathepsin H Neighboring gene Ras protein specific guanine nucleotide releasing factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in G-quadruplex DNA unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Bloom syndrome protein
Names
Bloom syndrome RecQ like helicase
Bloom syndrome protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xiphophorus maculatus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference X_maculatus-5.0-male Primary Assembly

Genomic

  1. NC_036444.1 Reference X_maculatus-5.0-male Primary Assembly

    Range
    9873961..9883971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023326274.1 → XP_023182042.1  Bloom syndrome protein isoform X2

    UniProtKB/TrEMBL
    M3ZL77
    Related
    ENSXMAP00000002969.1, ENSXMAT00000002974.2
    Conserved Domains (5) summary
    smart00341
    Location:1171 → 1249
    HRDC; Helicase and RNase D C-terminal
    pfam08072
    Location:344 → 383
    BDHCT; BDHCT (NUC031) domain
    pfam09507
    Location:86 → 295
    CDC27; DNA polymerase subunit Cdc27
    pfam16202
    Location:1 → 43
    BLM_N; N-terminal region of Bloom syndrome protein
    cl26939
    Location:616 → 1100
    DEXDc; DEAD-like helicases superfamily

  2. XM_005798275.2 → XP_005798332.1  Bloom syndrome protein isoform X1

    UniProtKB/TrEMBL
    A0A3B5Q8Z5
    Related
    ENSXMAP00000027372.1, ENSXMAT00000025557.1
    Conserved Domains (8) summary
    smart00341
    Location:1201 → 1279
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:646 → 1130
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    smart00956
    Location:1066 → 1169
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:850 → 981
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:661 → 830
    DEAD; DEAD/DEAH box helicase
    pfam08072
    Location:374 → 411
    BDHCT; BDHCT (NUC031) domain
    pfam16124
    Location:986 → 1055
    RecQ_Zn_bind; RecQ zinc-binding
    pfam16202
    Location:1 → 95
    BLM_N; N-terminal region of Bloom syndrome protein
Nucleotide Protein Strain
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