FBXW7-AS1 FBXW7 antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXW7-AS1provided by HGNC
Official Full Name: FBXW7 antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:52397
See related: Ensembl:ENSG00000270751 AllianceGenome:HGNC:52397
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DEAR; DEspR
Summary: Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: The ncRNA locus type is based on analysis of genome sequence data and RNA-seq samples. This gene has protein-coding potential in some circumstances (PMID:17446437, PMID:27301377), possibly through use of an ADAR1 RNA-editing mechanism (PMID:33853558). [13 Dec 2016]; Note: Be aware that the expression data shown for FBXW7-AS1 is from non-stranded files and not distinguished from that of FBXW7. [08 Aug 2023]
Expression: Broad expression in brain (RPKM 11.8), skin (RPKM 11.5) and 23 other tissues See more
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Genomic context

Location:: 4q31.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (152337674..152338096)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (155660829..155661251)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (153258826..153259248)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human DEspR+CD11b+ neutrophil levels correlate with neutrophil to lymphocyte ratio (NLR) and circulating NET-forming neutrophil (vital NETosis) levels in sICH patients.
Title: "Rogue" [DEspR+CD11b+] neutrophil subset correlates with severity in spontaneous intracerebral hemorrhage.
Human DEspR+ neutrophils are associated with hypertension in sICH patients.
Title: Expression of DEspR in acute intracerebral hemorrhage.
DEspR+ neutrophils are increased in bronchoalveolar lavage fluid neutrophils in response to intra-bronchial bacteriotoxin (lipopolysaccharide) stimulation in healthy volunteers.
Title: "Rogue" neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury - studies in human, macaque and rat LPS-inflammation models.
DEspR+CD11b+ neutrophils are associated with poor outcomes and severity of acute respiratory distress syndrome in critically ill patients.
Title: A targetable 'rogue' neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS.
DEspR+CD11b+ neutrophils are associated with poor outcomes in patients with spontaneous intracerebral hemorrhage (sICH) and severity of sICH.
Title: "Rogue" [DEspR+CD11b+] neutrophil subset correlates with severity in spontaneous intracerebral hemorrhage.
DEspR binds to endothelin-1 and to the signal peptide propeptide of VEGF-A (VEGF-sp), but no binding to VEGF-A
Title: Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.
DEspR(high) neutrophils are associated with critical illness in COVID-19.
Title: DEspR(high) neutrophils are associated with critical illness in COVID-19.
Data confirm translatability of DEspR, the full-length DEspR protein beyond codon#14, and elucidate DEspR-specific functionality.
Title: Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein.
DEspR activation would coordinate tumor progression events.
Title: DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a 'common receptor coordinator' paradigm.
A single nucleotide polymorphism within the DEspR 5'-regulatory region associated with increased blood pressure in a male Sardinian cohort, was identified.[DEdpR]
Title: DEspR T/CATAAAA-box promoter variant decreases DEspR transcription and is associated with increased BP in Sardinian males.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

dual endothelin-1(VEGFsp)/angiotensin II receptor
dual-endothelin1/VEGFsp receptor

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endothelin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endothelin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.