U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIMP3 TIMP metallopeptidase inhibitor 3 [ Capra hircus (goat) ]

Gene ID: 102190027, updated on 19-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
TIMP3
Gene description
TIMP metallopeptidase inhibitor 3
Gene type
protein coding
RefSeq status
MODEL
Organism
Capra hircus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TIMP3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
102 current ASM170441v1 (GCF_001704415.1) 5 NC_030812.1 (70075729..70134562)
101 previous assembly CHIR_1.0 (GCF_000317765.1) 5 NC_022297.1 (69303492..69316570)

Chromosome 5 - NC_030812.1Genomic Context describing neighboring genes Neighboring gene F-box protein 7 Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein pseudogene Neighboring gene synapsin III Neighboring gene protein HP-25 homolog 1 Neighboring gene protein HP-25 homolog 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression and regulative function of tissue inhibitor of metalloproteinase 3 in the goat ovary and its role in cultured granulosa cells. Peng J, et al. Mol Cell Endocrinol, 2015 Sep 5. PMID 26054746
  2. Expression and regulation of tissue inhibitors of metalloproteinases (TIMP1 and TIMP3) in goat oviduct. Peng J, et al. Theriogenology, 2015 Dec. PMID 26435260
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The differential regulation and function between TIMP1 and TIMP3 might be associated with their unique roles in fertilization and early embryonic development.
    Title: Expression and regulation of tissue inhibitors of metalloproteinases (TIMP1 and TIMP3) in goat oviduct.
  2. Induced expression of TIMP3 may play an important role in regulating goat granulosa cell survival and steroidogenesis.
    Title: Expression and regulative function of tissue inhibitor of metalloproteinase 3 in the goat ovary and its role in cultured granulosa cells.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
metalloproteinase inhibitor 3
Names
tissue inhibitor of metalloproteinase 3 precursor protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM170441v1 Primary Assembly

Genomic

  1. NC_030812.1 Reference ASM170441v1 Primary Assembly

    Range
    70075729..70134562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018048225.1 → XP_017903714.1  metalloproteinase inhibitor 3

    UniProtKB/TrEMBL
    A0A140C4Q7
    Conserved Domains (1) summary
    cd03585
    Location:24 → 200
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.