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ACLY ATP citrate lyase [ Capra hircus (goat) ]

Gene ID: 102181894, updated on 1-Aug-2024

Summary

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Gene symbol
ACLY
Gene description
ATP citrate lyase
See related
EnsemblRapid:ENSCHIG00000023185
Gene type
protein coding
RefSeq status
MODEL
Organism
Capra hircus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
Orthologs
human mouse all
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Genomic context

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See ACLY in Genome Data Viewer
Location:
chromosome: 19
Exon count:
30
Annotation release Status Assembly Chr Location
102 current ASM170441v1 (GCF_001704415.1) 19 NC_030826.1 (41695187..41737815, complement)
101 previous assembly CHIR_1.0 (GCF_000317765.1) 19 NC_022311.1 (41195364..41238857, complement)

Chromosome 19 - NC_030826.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 10 Neighboring gene kelch like family member 11 Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP citrate synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in citrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ATP-citrate synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM170441v1 Primary Assembly

Genomic

  1. NC_030826.1 Reference ASM170441v1 Primary Assembly

    Range
    41695187..41737815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005693833.3 → XP_005693890.1  ATP-citrate synthase isoform X1

    UniProtKB/TrEMBL
    A0A452FSM9, A0AAJ6SBA3
    Related
    ENSCHIP00000027233.2, ENSCHIT00000035101.2
    Conserved Domains (7) summary
    cd06100
    Location:873 → 1110
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 419
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:506 → 1111
    PLN02522; ATP citrate (pro-S)-lyase
    pfam16114
    Location:247 → 421
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:6 → 207
    ATP-grasp_4; ATP-grasp domain
    cl21454
    Location:514 → 617
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl22543
    Location:677 → 802
    Ligase_CoA; CoA-ligase

  2. XM_013972417.2 → XP_013827871.1  ATP-citrate synthase isoform X5

    UniProtKB/TrEMBL
    A0A452FSM9, A0AAJ7EPA5
    Conserved Domains (7) summary
    cd06100
    Location:900 → 1137
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:55 → 473
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:533 → 1138
    PLN02522; ATP citrate (pro-S)-lyase
    pfam16114
    Location:301 → 475
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:60 → 261
    ATP-grasp_4; ATP-grasp domain
    cl21454
    Location:541 → 644
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl22543
    Location:704 → 829
    Ligase_CoA; CoA-ligase

  3. XM_013972416.2 → XP_013827870.1  ATP-citrate synthase isoform X4

    UniProtKB/TrEMBL
    A0A452FSM9, A0AAJ7EPA8
    Conserved Domains (7) summary
    cd06100
    Location:910 → 1147
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:55 → 473
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:543 → 1148
    PLN02522; ATP citrate (pro-S)-lyase
    pfam16114
    Location:301 → 475
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:60 → 261
    ATP-grasp_4; ATP-grasp domain
    cl21454
    Location:551 → 654
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl22543
    Location:714 → 839
    Ligase_CoA; CoA-ligase

  4. XM_005693835.3 → XP_005693892.1  ATP-citrate synthase isoform X3

    UniProtKB/TrEMBL
    A0A452FSH4, A0A452FSM9
    Related
    ENSCHIP00000027230.1, ENSCHIT00000035098.2
    Conserved Domains (7) summary
    cd06100
    Location:846 → 1083
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 419
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:479 → 1084
    PLN02522; ATP citrate (pro-S)-lyase
    pfam16114
    Location:247 → 421
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:6 → 207
    ATP-grasp_4; ATP-grasp domain
    cl21454
    Location:487 → 590
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl22543
    Location:650 → 775
    Ligase_CoA; CoA-ligase

  5. XM_005693834.3 → XP_005693891.1  ATP-citrate synthase isoform X2

    UniProtKB/TrEMBL
    A0A452FSK9, A0A452FSM9
    Conserved Domains (7) summary
    cd06100
    Location:856 → 1093
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 419
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:489 → 1094
    PLN02522; ATP citrate (pro-S)-lyase
    pfam16114
    Location:247 → 421
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:6 → 207
    ATP-grasp_4; ATP-grasp domain
    cl21454
    Location:497 → 600
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl22543
    Location:660 → 785
    Ligase_CoA; CoA-ligase
Nucleotide Protein
Heading Accession and Version

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