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SSX3 SSX family member 3 [ Homo sapiens (human) ]

Gene ID: 10214, updated on 5-Mar-2024

Summary

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Official Symbol
SSX3provided by HGNC
Official Full Name
SSX family member 3provided by HGNC
Primary source
HGNC:HGNC:11337
See related
Ensembl:ENSG00000165584 MIM:300325; AllianceGenome:HGNC:11337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT5.3
Summary
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]
Expression
Restricted expression toward testis (RPKM 5.8) See more
Orthologs
all
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Genomic context

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Location:
Xp11.23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (48346427..48356703, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (47755403..47765669, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48205862..48216138, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SSX family member 19, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chrX:48186958-48187217 Neighboring gene S100A11 pseudogene 9 Neighboring gene ornithine aminotransferase pseudogene Neighboring gene ornithine aminotransferase, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas. de Leeuw B, et al. Cytogenet Cell Genet, 1996. PMID 8697803
  2. A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer. Yau C, et al. Breast Cancer Res, 2010. PMID 20946665, Free PMC Article
  3. SSX2-4 expression in early-stage non-small cell lung cancer. Greve KB, et al. Tissue Antigens, 2014 May. PMID 24645645
  4. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. dos Santos NR, et al. Cancer Res, 2000 Mar 15. PMID 10749136
  5. SSX: a multigene family with several members transcribed in normal testis and human cancer. Gure AO, et al. Int J Cancer, 1997 Sep 17. PMID 9378559

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14495, MGC119054

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein SSX3
Names
Kruppel-associated box containing gene product SSX3
cancer/testis antigen 5.3
synovial sarcoma, X breakpoint 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012561.1 RefSeqGene

    Range
    5005..15281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021014.4 → NP_066294.1  protein SSX3

    See identical proteins and their annotated locations for NP_066294.1

    Status: REVIEWED

    Source sequence(s)
    AA609599, AL606490, BC103862, U90840
    Consensus CDS
    CCDS14291.1
    UniProtKB/Swiss-Prot
    O60223, Q5JQZ3, Q99909, Q9BRW7
    Related
    ENSP00000298396.2, ENST00000298396.7
    Conserved Domains (2) summary
    smart00349
    Location:23 → 82
    KRAB; krueppel associated box
    pfam09514
    Location:156 → 187
    SSXRD; SSXRD motif

RNA

  1. NR_176964.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL606490

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    48346427..48356703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543885.3 → XP_011542187.1  protein SSX3 isoform X1

    See identical proteins and their annotated locations for XP_011542187.1

    Related
    ENSP00000366090.3, ENST00000376893.7
    Conserved Domains (1) summary
    smart00349
    Location:23 → 82
    KRAB; krueppel associated box

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    47755403..47765669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326359.1 → XP_054182334.1  protein SSX3 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175711.1: Suppressed sequence

    Description
    NM_175711.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99909.2 GenPept UniProtKB/Swiss-Prot:Q99909

Gene LinkOut

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