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TNF tumor necrosis factor [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102139631, updated on 10-Oct-2024

Summary

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Gene symbol
TNF
Gene description
tumor necrosis factor
See related
Ensembl:ENSMFAG00000040286
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
TNFA; TNF-a; TNFSF2; Cachectin; TNF-alpha
Orthologs
human mouse all
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Genomic context

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See TNF in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 4 NC_088378.1 (140153353..140156137, complement)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 4 NC_052258.1 (31725084..31727872)

Chromosome 4 - NC_088378.1Genomic Context describing neighboring genes Neighboring gene leukocyte specific transcript 1 Neighboring gene lymphotoxin beta Neighboring gene uncharacterized LOC107129571 Neighboring gene lymphotoxin alpha Neighboring gene NFKB inhibitor like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes. Uno Y, et al. Drug Metab Pharmacokinet, 2020 Jun. PMID 32253084
  2. Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection. Pan D, et al. J Gen Virol, 2019 Jan. PMID 30480508, Free PMC Article
  3. Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses. Epaulard O, et al. J Immunol, 2014 Sep 1. PMID 25057007, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-1beta and tumor necrosis factor-alpha affect cytochrome P450 expression in cynomolgus macaque hepatocytes.
    Title: Interleukin-1β and tumor necrosis factor-α affect cytochrome P450 expression in cynomolgus macaque hepatocytes.
  2. The reduction of CD58 expression in T cells was correlated with the reduced expression of T-cell-mediated IL-2 and TNFalpha production. Together, these results indicate that reduction in the CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.
    Title: Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.
  3. Macrophage- and neutrophil-derived TNF-alpha instructs skin langerhans cells to prime antiviral immune responses.
    Title: Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor
Names
tumor necrosis factor ligand superfamily member 2
tumor necrosis factor-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088378.1 Reference T2T-MFA8v1.0

    Range
    140153353..140156137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045390623.2 → XP_045246558.1  tumor necrosis factor

    UniProtKB/TrEMBL
    A0A2K5TRY1
    Conserved Domains (1) summary
    pfam00229
    Location:102 → 233
    TNF; TNF(tumor Necrosis Factor) family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001285277.1: Suppressed sequence

    Description
    NM_001285277.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79337.1 GenPept UniProtKB/Swiss-Prot:P79337

Gene LinkOut

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