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NCK1 NCK adaptor protein 1 [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102120560, updated on 10-Oct-2024

Summary

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Gene symbol
NCK1
Gene description
NCK adaptor protein 1
See related
Ensembl:ENSMFAG00000044882
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NCK1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 2 NC_088376.1 (39719705..39814348)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 2 NC_052256.1 (154987665..155081204, complement)

Chromosome 2 - NC_088376.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase 1 family member D1-like Neighboring gene solute carrier family 35 member G2 Neighboring gene uncharacterized LOC135969633 Neighboring gene U6 spliceosomal RNA Neighboring gene RAD51-associated protein 1-like Neighboring gene uncharacterized LOC135969635 Neighboring gene interleukin 20 receptor subunit beta Neighboring gene uncharacterized LOC135969634

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH2/SH3 adapter protein NCK1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088376.1 Reference T2T-MFA8v1.0

    Range
    39719705..39814348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_065539965.1 → XP_065396037.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  2. XM_065539967.1 → XP_065396039.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  3. XM_045386932.2 → XP_045242867.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  4. XM_065539962.1 → XP_065396034.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  5. XM_065539966.1 → XP_065396038.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  6. XM_005545858.4 → XP_005545915.1  SH2/SH3 adapter protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005545915.1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5, G7NXX3
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  7. XM_065539968.1 → XP_065396040.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  8. XM_045386933.2 → XP_045242868.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  9. XM_065539963.1 → XP_065396035.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  10. XM_065539970.1 → XP_065396042.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  11. XM_005545860.4 → XP_005545917.1  SH2/SH3 adapter protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_005545917.1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5, G7NXX3
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  12. XM_015445126.3 → XP_015300612.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5, G7NXX3
    Conserved Domains (4) summary
    cd10408
    Location:280 → 376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:3 → 61
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108 → 162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193 → 249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

  13. XM_065539964.1 → XP_065396036.1  SH2/SH3 adapter protein NCK1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5VQ82, A0A7N9D9X5

  14. XM_005545861.4 → XP_005545918.1  SH2/SH3 adapter protein NCK1 isoform X2

    See identical proteins and their annotated locations for XP_005545918.1

    UniProtKB/TrEMBL
    A0A2K5VQB6
    Related
    ENSMFAP00000026969.1
    Conserved Domains (3) summary
    cd10408
    Location:216 → 312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:44 → 98
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129 → 185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
Nucleotide Protein
Heading Accession and Version

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