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CAPN3 calpain 3 [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102115794, updated on 12-Jun-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
Ensembl:ENSMFAG00000008163
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
Cn94; Calpain-3
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 7 NC_088381.1 (18957785..19016784)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 7 NC_052261.1 (17899977..17958575)

Chromosome 7 - NC_088381.1Genomic Context describing neighboring genes Neighboring gene VPS39 subunit of HOPS complex Neighboring gene transmembrane protein 87A Neighboring gene glucosidase alpha, neutral C Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis. Singh RK, et al. Cell Rep, 2018 Jul 3. PMID 29972780, Free PMC Article
  2. Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues. Nakajima T, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406271

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of calpain complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3
Names
CANP 3
Calcium-activated neutral proteinase 3
Calpain L3
Calpain p94
Muscle-specific calcium-activated neutral protease 3
calpain 3, (p94)
XP_005559348.1
XP_005559351.1
XP_015307940.1
XP_015307943.1
XP_045253153.1
XP_045253154.1
XP_045253155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088381.1 Reference T2T-MFA8v1.0

    Range
    18957785..19016784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005559291.4 → XP_005559348.1  calpain-3 isoform X1

    See identical proteins and their annotated locations for XP_005559348.1

    UniProtKB/TrEMBL
    A0A2K5UIG7, G7PB02
    Related
    ENSMFAP00000012177.1
    Conserved Domains (4) summary
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:653 → 821
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III

  2. XM_045397218.2 → XP_045253153.1  calpain-3 isoform X2

    UniProtKB/Swiss-Prot
    Q9GLG7
    UniProtKB/TrEMBL
    G7PB02
    Conserved Domains (4) summary
    cd16190
    Location:647 → 815
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 574
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3

  3. XM_015452454.3 → XP_015307940.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    G7PB02
    Conserved Domains (5) summary
    cd00051
    Location:653 → 707
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:684 → 740
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:684 → 773
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_045397219.2 → XP_045253154.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    G7PB02

  5. XM_045397220.2 → XP_045253155.1  calpain-3 isoform X5

    Conserved Domains (4) summary
    cd16190
    Location:426 → 594
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam01067
    Location:209 → 347
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:356 → 426
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:1 → 188
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  6. XM_015452457.3 → XP_015307943.1  calpain-3 isoform X6

    Conserved Domains (6) summary
    cd00051
    Location:337 → 391
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:69 → 219
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:368 → 424
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:223 → 293
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:39 → 65
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl08302
    Location:293 → 361
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_005559294.4 → XP_005559351.1  calpain-3 isoform X7

    See identical proteins and their annotated locations for XP_005559351.1

    Conserved Domains (3) summary
    pfam01067
    Location:1 → 67
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:71 → 141
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:141 → 309
    EFh_PEF_CAPN3; Calcium-activated neutral

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001287701.1: Suppressed sequence

    Description
    NM_001287701.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GLG7.1 GenPept UniProtKB/Swiss-Prot:Q9GLG7

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