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Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 [ Mus musculus (house mouse) ]

Gene ID: 102098, updated on 18-Sep-2024

Summary

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Official Symbol
Arhgef18provided by MGI
Official Full Name
Rho/Rac guanine nucleotide exchange factor 18provided by MGI
Primary source
MGI:MGI:2142567
See related
Ensembl:ENSMUSG00000004568 AllianceGenome:MGI:2142567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A430078G23Rik; D030053O22Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly; protein localization to cell-cell junction; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in apical part of cell and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; dermis; epidermis; and metanephros. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 41.5), thymus adult (RPKM 26.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgef18 in Genome Data Viewer
Location:
8 A1.1; 8 1.92 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3403339..3506601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3353338..3456601)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 88 Neighboring gene insulin receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:3354554-3354663 Neighboring gene predicted gene, 30369 Neighboring gene STARR-seq mESC enhancer starr_20578 Neighboring gene predicted gene, 46029 Neighboring gene STARR-positive B cell enhancer ABC_E10487 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5 Neighboring gene zinc finger protein 358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation. Xu X, et al. Mol Cell Biol, 2013 Jul. PMID 23648482, Free PMC Article
  2. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Tsuji T, et al. Mol Biol Cell, 2010 Oct 15. PMID 20810787, Free PMC Article
  3. The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier. Schell C, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28536193, Free PMC Article
  4. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
  5. The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Boglev Y, et al. Dev Biol, 2011 Jan 15. PMID 21081122

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 18
Names
rho/rac guanine nucleotide exchange factor (GEF) 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370668.1 → NP_001357597.1  rho guanine nucleotide exchange factor 18 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC169677
    UniProtKB/Swiss-Prot
    E9QK59, Q6A055, Q6P9R4, Q8BYA4, Q8K227
    UniProtKB/TrEMBL
    A0A5F8MPH6
    Related
    ENSMUSP00000158969.2, ENSMUST00000239102.2
    Conserved Domains (4) summary
    cd00160
    Location:486 → 680
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:721 → 839
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1044 → 1165
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:1124 → 1276
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  2. NM_133962.4 → NP_598723.3  rho guanine nucleotide exchange factor 18 isoform 2

    See identical proteins and their annotated locations for NP_598723.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) results from the use of an alternate downstream promoter and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK041423, AK083608, BC060639, BQ830835, CA749983
    Consensus CDS
    CCDS22060.1
    UniProtKB/TrEMBL
    A0A5F8MPF6
    Related
    ENSMUSP00000004684.7, ENSMUST00000004684.13
    Conserved Domains (4) summary
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:337 → 455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:667 → 783
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:740 → 892
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    3403339..3506601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243210.2 → XP_030099070.1  rho guanine nucleotide exchange factor 18 isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPH6
    Conserved Domains (4) summary
    PRK13729
    Location:1132 → 1284
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:486 → 680
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:721 → 839
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1059 → 1176
    DUF5401; Family of unknown function (DUF5401)

  2. XM_030243212.2 → XP_030099072.1  rho guanine nucleotide exchange factor 18 isoform X3

    UniProtKB/TrEMBL
    A0A5F8MPH6
    Conserved Domains (4) summary
    PRK13729
    Location:1071 → 1223
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:425 → 619
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:660 → 778
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:998 → 1115
    DUF5401; Family of unknown function (DUF5401)

  3. XM_030243209.2 → XP_030099069.1  rho guanine nucleotide exchange factor 18 isoform X1

    UniProtKB/TrEMBL
    A0A5F8MPH6
    Conserved Domains (4) summary
    PRK13729
    Location:1153 → 1305
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:515 → 709
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:750 → 868
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:1080 → 1197
    DUF5401; Family of unknown function (DUF5401)

  4. XM_030243211.2 → XP_030099071.1  rho guanine nucleotide exchange factor 18 isoform X3

    UniProtKB/TrEMBL
    A0A5F8MPH6
    Conserved Domains (4) summary
    PRK13729
    Location:1071 → 1223
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:425 → 619
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:660 → 778
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:998 → 1115
    DUF5401; Family of unknown function (DUF5401)

  5. XM_006508682.4 → XP_006508745.1  rho guanine nucleotide exchange factor 18 isoform X4

    See identical proteins and their annotated locations for XP_006508745.1

    UniProtKB/TrEMBL
    A0A5F8MPF6
    Conserved Domains (4) summary
    PRK13729
    Location:748 → 900
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:337 → 455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:675 → 775
    DUF5401; Family of unknown function (DUF5401)

  6. XM_036153699.1 → XP_036009592.1  rho guanine nucleotide exchange factor 18 isoform X5

    UniProtKB/TrEMBL
    A0A5F8MPF6
    Conserved Domains (4) summary
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:337 → 455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:667 → 783
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:740 → 892
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  7. XM_017312501.3 → XP_017167990.1  rho guanine nucleotide exchange factor 18 isoform X4

    UniProtKB/TrEMBL
    A0A5F8MPF6
    Conserved Domains (4) summary
    PRK13729
    Location:748 → 900
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:337 → 455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:675 → 775
    DUF5401; Family of unknown function (DUF5401)

  8. XM_036153700.1 → XP_036009593.1  rho guanine nucleotide exchange factor 18 isoform X5

    UniProtKB/TrEMBL
    A0A5F8MPF6
    Conserved Domains (4) summary
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:337 → 455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:667 → 783
    DUF5401; Family of unknown function (DUF5401)
    cl28929
    Location:740 → 892
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

  9. XM_006508681.4 → XP_006508744.1  rho guanine nucleotide exchange factor 18 isoform X4

    See identical proteins and their annotated locations for XP_006508744.1

    UniProtKB/TrEMBL
    A0A5F8MPF6
    Conserved Domains (4) summary
    PRK13729
    Location:748 → 900
    PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
    cd00160
    Location:102 → 296
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd15794
    Location:337 → 455
    PH_ARHGEF18; Rho guanine nucleotide exchange factor 18 Pleckstrin homology (PH) domain
    pfam17380
    Location:675 → 775
    DUF5401; Family of unknown function (DUF5401)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033378.3: Suppressed sequence

    Description
    NM_001033378.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9R4.3 GenPept UniProtKB/Swiss-Prot:Q6P9R4

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