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LYN LYN proto-oncogene, Src family tyrosine kinase [ Columba livia (rock pigeon) ]

Gene ID: 102084226, updated on 3-Aug-2024

Summary

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Gene symbol
LYN
Gene description
LYN proto-oncogene, Src family tyrosine kinase
Gene type
protein coding
RefSeq status
MODEL
Organism
Columba livia
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Columbimorphae; Columbiformes; Columbidae; Columba
Orthologs
human mouse all
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Genomic context

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See LYN in Genome Data Viewer
Location:
chromosome: 2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_05 current bColLiv1.pat.W.v2 (GCF_036013475.1) 2 NC_088603.1 (122054938..122107905)
102 previous assembly Cliv_1.0 (GCF_000337935.1) Unplaced Scaffold NW_004973399.1 (4479398..4527635, complement)

Chromosome 2 - NC_088603.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC135578635 Neighboring gene trimethylguanosine synthase 1 Neighboring gene uncharacterized LOC135578636 Neighboring gene kinesin-like protein KIF20A Neighboring gene small nucleolar RNA U54 Neighboring gene ribosomal protein S20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic diversity and evolution of the head crest in the rock pigeon. Shapiro MD, et al. Science, 2013 Mar 1. PMID 23371554, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in Fc receptor mediated stimulatory signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of mast cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of dendritic cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tolerance induction to self antigen IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Lyn
Names
Tyrosine-protein kinase Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036013475.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bColLiv1.pat.W.v2

Genomic

  1. NC_088603.1 Reference bColLiv1.pat.W.v2

    Range
    122054938..122107905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_065053578.1 → XP_064909650.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A2I0MVY9

  2. XM_065053573.1 → XP_064909645.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A2I0MVY8

  3. XM_065053572.1 → XP_064909644.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A2I0MVY9

  4. XM_065053574.1 → XP_064909646.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A2I0MVY8

  5. XM_005506499.3 → XP_005506556.1  tyrosine-protein kinase Lyn isoform X1

    See identical proteins and their annotated locations for XP_005506556.1

    UniProtKB/TrEMBL
    A0A2I0MVY9
    Conserved Domains (3) summary
    cd10364
    Location:126 → 226
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:68 → 123
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:240 → 511
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  6. XM_065053576.1 → XP_064909648.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A2I0MVY8

  7. XM_065053577.1 → XP_064909649.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A2I0MVY8
Nucleotide Protein
Heading Accession and Version

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