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ZNF433-AS1 ZNF433 and ZNF878 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 101928464, updated on 10-Oct-2023

Summary

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Official Symbol
ZNF433-AS1provided by HGNC
Official Full Name
ZNF433 and ZNF878 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:53776
See related
Ensembl:ENSG00000219665 AllianceGenome:HGNC:53776
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 2.1), bone marrow (RPKM 1.2) and 24 other tissues See more
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Genomic context

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Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11987617..12046275)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12115811..12174482)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12098432..12157090)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 69 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12074983-12075936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10136 Neighboring gene vomeronasal 2 receptor 21 pseudogene Neighboring gene zinc finger protein 763 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12098284-12099226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12099227-12100168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14042 Neighboring gene RNA, 5S ribosomal pseudogene 464 Neighboring gene zinc finger protein 433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10139 Neighboring gene RNA, 5S ribosomal pseudogene 465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:12163610-12164115 Neighboring gene zinc finger protein 878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10141 Neighboring gene RNA, 5S ribosomal pseudogene 466 Neighboring gene zinc finger protein 844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10143 Neighboring gene ribosomal L24 domain containing 1 pseudogene 8 Neighboring gene zinc finger family member 788, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. Nischwitz S, et al. J Neuroimmunol, 2010 Oct 8. PMID 20598377
  2. cDNA microarray analysis of altered gene expression in Ara-C-treated leukemia cells. Takagaki K, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951057
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_134927.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC042379
    Related
    ENST00000406892.6

  2. NR_134928.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks one exon and contains two alternate exons, compared to variant 1.
    Source sequence(s)
    BC042379, BM717321
    Related
    ENST00000476474.5

  3. NR_134929.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons and contains two alternate exons, compared to variant 1.
    Source sequence(s)
    AA431306, BC042379, BP428722

  4. NR_134930.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks one exon and contains one alternate exon, compared to variant 1.
    Source sequence(s)
    BC042379, BG059081, BM854799
    Related
    ENST00000489336.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11987617..12046275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12115811..12174482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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