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AQP5-AS1 AQP5 and AQP2 antisense RNA 2 [ Homo sapiens (human) ]

Gene ID: 101927318, updated on 25-Jan-2024

Summary

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Official Symbol
AQP5-AS1provided by HGNC
Official Full Name
AQP5 and AQP2 antisense RNA 2provided by HGNC
Primary source
HGNC:HGNC:55474
See related
Ensembl:ENSG00000257588 AllianceGenome:HGNC:55474
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIAC
Expression
Restricted expression toward kidney (RPKM 57.0) See more
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Genomic context

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See AQP5-AS1 in Genome Data Viewer
Location:
12q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49951512..49962924, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49914503..49925913, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50345295..50356707, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2395 Neighboring gene uncharacterized LOC124902930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50335615-50336600 Neighboring gene uncharacterized LOC105369763 Neighboring gene NANOG-H3K4me1 hESC enhancers GRCh37_chr12:50338782-50339658 and GRCh37_chr12:50339659-50340534 Neighboring gene aquaporin 2 Neighboring gene uncharacterized LOC105369764 Neighboring gene Sharpr-MPRA regulatory region 13914 Neighboring gene aquaporin 5 Neighboring gene aquaporin 6 Neighboring gene Rac GTPase activating protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6338 Neighboring gene Sharpr-MPRA regulatory region 11175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma. Li M, et al. Mol Cancer, 2022 Sep 19. PMID 36117171, Free PMC Article
  2. Micropeptide MIAC Inhibits HNSCC Progression by Interacting with Aquaporin 2. Li M, et al. J Am Chem Soc, 2020 Apr 8. PMID 32176498
  3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • micropeptide inhibiting actin cytoskeleton

Clone Names

  • AC025154.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110589.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and includes a distinct 3' terminal exon compared to variant 1.
    Source sequence(s)
    BM931698

  2. NR_110590.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant may be partial at the 3' end.
    Source sequence(s)
    BM839521, DB200798
    Related
    ENST00000552379.1

  3. NR_110591.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks one alternate exon and includes one alternate exon compared to variant 1. This variant may be partial at the 3' end.
    Source sequence(s)
    AC025154
    Related
    ENST00000550530.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    49951512..49962924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    49914503..49925913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A7L8Y648.1 GenPept UniProtKB/Swiss-Prot:A0A7L8Y648

Gene LinkOut

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