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NEDD4L NEDD4 like E3 ubiquitin protein ligase [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 101867463, updated on 10-Oct-2024

Summary

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Gene symbol
NEDD4L
Gene description
NEDD4 like E3 ubiquitin protein ligase
See related
Ensembl:ENSMFAG00000032021
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See NEDD4L in Genome Data Viewer
Location:
chromosome: 18
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 18 NC_088392.1 (22572727..22941601, complement)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 18 NC_052272.1 (21733199..22100853, complement)

Chromosome 18 - NC_088392.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102130567 Neighboring gene uncharacterized LOC107128072 Neighboring gene uncharacterized LOC135968223 Neighboring gene U6 spliceosomal RNA Neighboring gene probable ribosome biogenesis protein RLP24 Neighboring gene uncharacterized LOC135968224 Neighboring gene ATPase phospholipid transporting 8B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rate of evolution in brain-expressed genes in humans and other primates. Wang HY, et al. PLoS Biol, 2007 Feb. PMID 17194215, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sodium channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of sodium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEDD4-like
Names
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088392.1 Reference T2T-MFA8v1.0

    Range
    22572727..22941601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015439728.3 → XP_015295214.2  E3 ubiquitin-protein ligase NEDD4-like isoform X15

    Conserved Domains (4) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:529 → 561
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:622 → 951
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:367 → 396
    WW; WW domain

  2. XM_015439726.3 → XP_015295212.2  E3 ubiquitin-protein ligase NEDD4-like isoform X13

    Conserved Domains (5) summary
    cd04033
    Location:21 → 153
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:549 → 581
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:642 → 971
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    PHA03247
    Location:319 → 502
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:387 → 416
    WW; WW domain

  3. XM_045377772.2 → XP_045233707.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

    Conserved Domains (4) summary
    cd04033
    Location:25 → 157
    C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
    smart00456
    Location:533 → 565
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:626 → 955
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:371 → 400
    WW; WW domain

  4. XM_045377771.2 → XP_045233706.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

    UniProtKB/TrEMBL
    A0A2K5V0L9

  5. XM_065533752.1 → XP_065389824.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

  6. XM_005586592.4 → XP_005586649.2  E3 ubiquitin-protein ligase NEDD4-like isoform X18

    Conserved Domains (4) summary
    smart00456
    Location:408 → 440
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:501 → 830
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00397
    Location:246 → 275
    WW; WW domain
    cl14603
    Location:1 → 32
    C2; C2 domain

  7. XM_065533753.1 → XP_065389825.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

  8. XM_065533741.1 → XP_065389813.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

    UniProtKB/TrEMBL
    A0A2K5V0E8

  9. XM_065533747.1 → XP_065389819.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  10. XM_065533742.1 → XP_065389814.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

  11. XM_065533740.1 → XP_065389812.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

    UniProtKB/TrEMBL
    A0A2K5V0F6

  12. XM_065533754.1 → XP_065389826.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  13. XM_065533749.1 → XP_065389821.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  14. XM_065533748.1 → XP_065389820.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  15. XM_065533751.1 → XP_065389823.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  16. XM_065533745.1 → XP_065389817.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  17. XM_065533744.1 → XP_065389816.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  18. XM_065533743.1 → XP_065389815.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  19. XM_065533746.1 → XP_065389818.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  20. XM_065533750.1 → XP_065389822.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  21. XM_065533755.1 → XP_065389827.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

  22. XM_065533739.1 → XP_065389811.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

  23. XM_065533738.1 → XP_065389810.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

  24. XM_065533737.1 → XP_065389809.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

  25. XM_065533736.1 → XP_065389808.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

  26. XM_065533735.1 → XP_065389807.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

  27. XM_065533734.1 → XP_065389806.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

  28. XM_065533733.1 → XP_065389805.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

  29. XM_065533732.1 → XP_065389804.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

Nucleotide Protein
Heading Accession and Version

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