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Arhgap12 Rho GTPase activating protein 12 [ Mesocricetus auratus (golden hamster) ]

Gene ID: 101831445, updated on 8-Mar-2024

Summary

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Gene symbol
Arhgap12
Gene description
Rho GTPase activating protein 12
See related
EnsemblRapid:ENSMAUG00000017573
Gene type
protein coding
RefSeq status
MODEL
Organism
Mesocricetus auratus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
Orthologs
human mouse all
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Genomic context

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See Arhgap12 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
103 current BCM_Maur_2.0 (GCF_017639785.1) Unplaced Scaffold NW_024429196.1 (8529878..8619492)
102 previous assembly MesAur1.0 (GCF_000349665.1) Unplaced Scaffold NW_004801788.1 (428471..531465)

NW_024429196.1Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2-like Neighboring gene low molecular weight phosphotyrosine protein phosphatase-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC121143483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters. McCann KE, et al. Sci Rep, 2017 Jan 10. PMID 28071753, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho GTPase-activating protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mesocricetus auratus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Maur_2.0 Primary Assembly

Genomic

  1. NW_024429196.1 Reference BCM_Maur_2.0 Primary Assembly

    Range
    8529878..8619492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005085161.4 → XP_005085218.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A1U7RBC9
    Related
    ENSMAUP00000019255.1, ENSMAUT00000023229.2
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:646 → 831
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:457 → 568
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  2. XM_005085162.4 → XP_005085219.1  rho GTPase-activating protein 12 isoform X2

    UniProtKB/TrEMBL
    A0A1U7RDY4
    Related
    ENSMAUP00000019257.1, ENSMAUT00000023231.2
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:621 → 806
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:432 → 543
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:442 → 541
    PH; PH domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  3. XM_005085165.4 → XP_005085222.1  rho GTPase-activating protein 12 isoform X3

    UniProtKB/TrEMBL
    A0A1U7R3R9
    Related
    ENSMAUP00000019270.2, ENSMAUT00000023244.2
    Conserved Domains (6) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:599 → 784
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:410 → 521
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:420 → 519
    PH; PH domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  4. XM_021236014.2 → XP_021091673.1  rho GTPase-activating protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A1U7RBC9
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd00201
    Location:266 → 296
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd04403
    Location:646 → 831
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:457 → 568
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

  5. XM_021236015.2 → XP_021091674.1  rho GTPase-activating protein 12 isoform X4

    UniProtKB/TrEMBL
    A0A3Q0DH78
    Conserved Domains (5) summary
    cd12070
    Location:13 → 72
    SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
    cd04403
    Location:574 → 759
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:385 → 496
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam16618
    Location:69 → 264
    SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    cl00157
    Location:257 → 362
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
Nucleotide Protein
Heading Accession and Version

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