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Nsd2 nuclear receptor binding SET domain protein 2 [ Mesocricetus auratus (golden hamster) ]

Gene ID: 101825729, updated on 8-Mar-2024

Summary

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Gene symbol
Nsd2
Gene description
nuclear receptor binding SET domain protein 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Mesocricetus auratus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
Also known as
Whsc1
Orthologs
human mouse all
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Genomic context

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See Nsd2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
103 current BCM_Maur_2.0 (GCF_017639785.1) Unplaced Scaffold NW_024429190.1 (14022880..14104950)
102 previous assembly MesAur1.0 (GCF_000349665.1) Unplaced Scaffold NW_004801619.1 (20675517..20753543, complement)

NW_024429190.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene negative elongation factor complex member A Neighboring gene NELL2 interacting cell ontogeny regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome sequencing and development of an expression microarray platform for liver infection in adenovirus type 5-infected Syrian golden hamsters. Ying B, et al. Virology, 2015 Nov. PMID 26319212, Free PMC Article
  2. De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters. McCann KE, et al. Sci Rep, 2017 Jan 10. PMID 28071753, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase NSD2
Names
Wolf-Hirschhorn syndrome candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mesocricetus auratus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference BCM_Maur_2.0 Primary Assembly

Genomic

  1. NW_024429190.1 Reference BCM_Maur_2.0 Primary Assembly

    Range
    14022880..14104950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040746906.1 → XP_040602840.1  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A1U8BP37
    Conserved Domains (12) summary
    cd05837
    Location:220 → 339
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:880 → 974
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1014 → 1064
    AWS; associated with SET domains
    COG5034
    Location:549 → 712
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:460 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15648
    Location:671 → 713
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15651
    Location:718 → 764
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:765 → 818
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1243 → 1285
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1064 → 1205
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    pfam17982
    Location:1284 → 1329
    C5HCH; NSD Cys-His rich domain
    cl22851
    Location:835 → 875
    PHD_SF; PHD finger superfamily

  2. XM_040746907.1 → XP_040602841.1  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A1U8BP37
    Conserved Domains (12) summary
    cd05837
    Location:220 → 339
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:880 → 974
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1014 → 1064
    AWS; associated with SET domains
    COG5034
    Location:549 → 712
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:460 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15648
    Location:671 → 713
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15651
    Location:718 → 764
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:765 → 818
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1243 → 1285
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1064 → 1205
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    pfam17982
    Location:1284 → 1329
    C5HCH; NSD Cys-His rich domain
    cl22851
    Location:835 → 875
    PHD_SF; PHD finger superfamily

  3. XM_040746903.1 → XP_040602837.1  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A1U8BP37
    Conserved Domains (12) summary
    cd05837
    Location:220 → 339
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:880 → 974
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1014 → 1064
    AWS; associated with SET domains
    COG5034
    Location:549 → 712
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:460 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15648
    Location:671 → 713
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15651
    Location:718 → 764
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:765 → 818
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1243 → 1285
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1064 → 1205
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    pfam17982
    Location:1284 → 1329
    C5HCH; NSD Cys-His rich domain
    cl22851
    Location:835 → 875
    PHD_SF; PHD finger superfamily

  4. XM_040746908.1 → XP_040602842.1  histone-lysine N-methyltransferase NSD2 isoform X2

    Conserved Domains (2) summary
    cd05837
    Location:220 → 339
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:460 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  5. XM_040746904.1 → XP_040602838.1  histone-lysine N-methyltransferase NSD2 isoform X1

    UniProtKB/TrEMBL
    A0A1U8BP37
    Conserved Domains (12) summary
    cd05837
    Location:220 → 339
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:880 → 974
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1014 → 1064
    AWS; associated with SET domains
    COG5034
    Location:549 → 712
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:460 → 507
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15648
    Location:671 → 713
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15651
    Location:718 → 764
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:765 → 818
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1243 → 1285
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cd19211
    Location:1064 → 1205
    SET_NSD2; SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
    pfam17982
    Location:1284 → 1329
    C5HCH; NSD Cys-His rich domain
    cl22851
    Location:835 → 875
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version

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