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CCAT2 colon cancer associated transcript 2 [ Homo sapiens (human) ]

Gene ID: 101805488, updated on 7-Apr-2024

Summary

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Official Symbol
CCAT2provided by HGNC
Official Full Name
colon cancer associated transcript 2provided by HGNC
Primary source
HGNC:HGNC:47044
See related
Ensembl:ENSG00000280997 MIM:619403; AllianceGenome:HGNC:47044
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCCP1; LINC00873
Summary
This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017]
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Genomic context

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Location:
8q24.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127400399..127402150)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (128527937..128529688)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128412644..128414395)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27934 Neighboring gene CCAT1 intron CAGE-defined B cell enhancer Neighboring gene Sharpr-MPRA regulatory region 9947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27936 Neighboring gene colon cancer associated transcript 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128264283-128264878 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27938 Neighboring gene cancer susceptibility 21 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128295539-128296172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128304713-128305280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27940 Neighboring gene cancer susceptibility 8 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128352096-128353295 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128383298-128383801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128444461-128445375 Neighboring gene POU class 5 homeobox 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19528 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128620950-128621545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27946 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658093-128658594 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658595-128659094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128672691-128673890 Neighboring gene uncharacterized LOC105375754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation. Gao H, et al. Sci Rep, 2022 Dec 8. PMID 36482069, Free PMC Article
  2. CCAT2 knockdown inhibits cell growth, and migration and promotes apoptosis through regulating the hsa-mir-145-5p/AKT3/mTOR axis in tamoxifen-resistant MCF7 cells. Moradi F, et al. Life Sci, 2022 Dec 15. PMID 36375570
  3. Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancers. Ma S, et al. Chin Med J (Engl), 2022 Dec 5. PMID 36103972, Free PMC Article
  4. Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer. Cao X, et al. J Ovarian Res, 2022 Feb 3. PMID 35115025, Free PMC Article
  5. Expression of lncRNA CCAT2 in children with neuroblastoma and its effect on cancer cell growth. Chen M, et al. Mol Cell Biochem, 2021 Apr. PMID 33475889

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression.
    Title: lncRNA CCAT2 Protects Against Cardiomyocyte Injury After Myocardial Ischemia/Reperfusion by Regulating BMI1 Expression.
  2. LncRNA CCAT2 promotes malignant progression of metastatic gastric cancer through regulating CD44 alternative splicing.
    Title: LncRNA CCAT2 promotes malignant progression of metastatic gastric cancer through regulating CD44 alternative splicing.
  3. Knockdown of Long Noncoding RNA CCAT2 Suppresses Malignant Phenotype in Human Laryngeal Squamous Cell Carcinoma.
    Title: Knockdown of Long Noncoding RNA CCAT2 Suppresses Malignant Phenotype in Human Laryngeal Squamous Cell Carcinoma.
  4. Long non-coding RNAs CCAT1 and CCAT2 in colorectal liver metastases are tumor-suppressive via MYC interaction and might predict patient outcomes.
    Title: Long non-coding RNAs CCAT1 and CCAT2 in colorectal liver metastases are tumor-suppressive via MYC interaction and might predict patient outcomes.
  5. Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancers.
    Title: Long non-coding RNA colon cancer-associated transcript 2: role and function in human cancers.
  6. LncRNA CCAT2, involving miR-34a/TGF-beta1/Smad4 signaling, regulate hepatic stellate cells proliferation.
    Title: LncRNA CCAT2, involving miR-34a/TGF-β1/Smad4 signaling, regulate hepatic stellate cells proliferation.
  7. CCAT2 knockdown inhibits cell growth, and migration and promotes apoptosis through regulating the hsa-mir-145-5p/AKT3/mTOR axis in tamoxifen-resistant MCF7 cells.
    Title: CCAT2 knockdown inhibits cell growth, and migration and promotes apoptosis through regulating the hsa-mir-145-5p/AKT3/mTOR axis in tamoxifen-resistant MCF7 cells.
  8. Effect of long noncoding RNA CCAT2 on drug sensitivity to 5-fluorouracil of breast cancer cells through microRNA-145 meditated by p53.
    Title: Effect of long noncoding RNA CCAT2 on drug sensitivity to 5-fluorouracil of breast cancer cells through microRNA-145 meditated by p53.
  9. Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer.
    Title: Serum CCAT2 as a biomarker for adjuvant diagnosis and prognostic prediction of cervical cancer.
  10. Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity.
    Title: Long non-coding RNA CCAT2 drives the growth of laryngeal squamous cell carcinoma via regulating YAP activity.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
EBI GWAS Catalog
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
EBI GWAS Catalog
Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population.
EBI GWAS Catalog
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
EBI GWAS Catalog
Genome-wide association scan for variants associated with early-onset prostate cancer.
EBI GWAS Catalog
Genome-wide association study identifies new prostate cancer susceptibility loci.
EBI GWAS Catalog
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.
EBI GWAS Catalog
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
EBI GWAS Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
EBI GWAS Catalog
Multiple loci identified in a genome-wide association study of prostate cancer.
EBI GWAS Catalog
Multiple newly identified loci associated with prostate cancer susceptibility.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • colon cancer associated transcript 2 (non-protein coding)
  • long intergenic non-protein coding RNA 873
  • non-coding RNA involved in cancer predisposition 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_109834.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC018714
    Related
    ENST00000630920.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    127400399..127402150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    128527937..128529688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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