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PRF1 perforin 1 [ Gallus gallus (chicken) ]

Gene ID: 101750363, updated on 10-Oct-2024

Summary

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Symbol
PRF1provided by CGNC
Full Name
perforin 1provided by CGNC
Primary source
CGNC:69815
See related
Ensembl:ENSGALG00010028016
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
P1; PFP; PFN1; perforin; cytolysin; perforin-1; perforin-1-like
Orthologs
human mouse all
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Genomic context

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See PRF1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (912240..915840)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (318964..322563)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107088 Neighboring gene uncharacterized LOC121107088 Neighboring gene coiled-coil domain containing 189 Neighboring gene uncharacterized LOC124417276 Neighboring gene ankyrin repeat and MYND domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterising an unusual perforin from chicken (Gallus gallus). D'Angelo ME, et al. Dev Comp Immunol, 2013 Oct. PMID 23680640
  2. Expression of perforin, granzyme A and Fas ligand mRNA in caecal tissues upon Eimeria tenella infection of naïve and immune chickens. Wattrang E, et al. Parasite Immunol, 2016 Jul. PMID 27136454
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. During primary Eimeria tenella infection, perforin, granzyme A and FasL mRNA expression in caecal tissue was significantly increased.
    Title: Expression of perforin, granzyme A and Fas ligand mRNA in caecal tissues upon Eimeria tenella infection of naïve and immune chickens.
  2. Findings indicate that perforin exists in birds, and is considerably longer than perforin of non-avian vertebrates.
    Title: Cloning and characterising an unusual perforin from chicken (Gallus gallus).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pore-forming activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in leukocyte mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
perforin-1
Names
lymphocyte pore forming protein
perforin 1 (pore forming protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    912240..915840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901804.1 → XP_046757760.1  perforin-1

    UniProtKB/TrEMBL
    R4QNW4
    Related
    ENSGALP00010041647.1, ENSGALT00010067904.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    318964..322563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929135.1 → XP_046785091.1  perforin-1

Nucleotide Protein
Heading Accession and Version

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