The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference ASM1176430v1.1 Primary Assembly

Genomic

1. NW_025422087.1 Reference ASM1176430v1.1 Primary Assembly

   Range

   18343878..18632727

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. XM_013061142.2 → XP_012916596.1  pappalysin-2

   UniProtKB/TrEMBL

   M3Y114

   Related

   ENSMPUP00000005015.1

   Conserved Domains (8) summary

   cd00033
   Location:1519 → 1585

   CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

   smart00004
   Location:1716 → 1752

   NL; Domain found in Notch and Lin-12

   TIGR02232
   Location:1107 → 1146

   myxo_disulf_rpt; Myxococcus cysteine-rich repeat

   cd04275
   Location:629 → 826

   ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...

   pfam00084
   Location:1461 → 1515

   Sushi; Sushi repeat (SCR repeat)

   pfam13948
   Location:1108 → 1139

   DUF4215; Domain of unknown function (DUF4215)

   cl02419
   Location:580 → 607

   Notch; LNR domain

   cl22861
   Location:281 → 428

   LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...