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CAPN3 calpain 3 [ Mustela putorius furo (domestic ferret) ]

Gene ID: 101675191, updated on 8-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
Ensembl:ENSMPUG00000009829
Gene type
protein coding
RefSeq status
MODEL
Organism
Mustela putorius furo (sub-species: furo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Mustela
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
25
Annotation release Status Assembly Chr Location
102 current ASM1176430v1.1 (GCF_011764305.1) Unplaced Scaffold NW_025422047.1 (9173508..9223163)
101 previous assembly MusPutFur1.0 (GCF_000215625.1) Unplaced Scaffold NW_004569170.1 (9041464..9091598)

NW_025422047.1Genomic Context describing neighboring genes Neighboring gene glucosidase alpha, neutral C Neighboring gene U4 spliceosomal RNA Neighboring gene 40S ribosomal protein S7 Neighboring gene zinc finger protein 106 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene synaptosome associated protein 23 Neighboring gene uncharacterized LOC123388367

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mustela putorius furo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1176430v1.1 Primary Assembly

Genomic

  1. NW_025422047.1 Reference ASM1176430v1.1 Primary Assembly

    Range
    9173508..9223163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004751191.3 → XP_004751248.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    M3YEJ8
    Related
    ENSMPUP00000009755.1
    Conserved Domains (6) summary
    cd00051
    Location:697 → 751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:728 → 784
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:653 → 722
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_004751192.3 → XP_004751249.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A8U0SUV8
    Conserved Domains (6) summary
    cd00051
    Location:691 → 745
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:722 → 778
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:647 → 716
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_004751194.3 → XP_004751251.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A8U0MQR9
    Conserved Domains (6) summary
    cd00051
    Location:649 → 703
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381 → 531
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:680 → 736
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:535 → 605
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:605 → 674
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_004751197.3 → XP_004751254.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A8U0SUY1
    Conserved Domains (6) summary
    cd00051
    Location:470 → 524
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:202 → 352
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:501 → 557
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:356 → 426
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:1 → 188
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl08302
    Location:426 → 495
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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