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DGKA diacylglycerol kinase alpha [ Mustela putorius furo (domestic ferret) ]

Gene ID: 101673748, updated on 18-Sep-2024

Summary

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Gene symbol
DGKA
Gene description
diacylglycerol kinase alpha
See related
Ensembl:ENSMPUG00000000935
Gene type
protein coding
RefSeq status
MODEL
Organism
Mustela putorius furo (sub-species: furo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Mustela
Orthologs
human mouse all
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Genomic context

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See DGKA in Genome Data Viewer
Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
102 current ASM1176430v1.1 (GCF_011764305.1) Unplaced Scaffold NW_025422127.1 (1474217..1495932)
101 previous assembly MusPutFur1.0 (GCF_000215625.1) Unplaced Scaffold NW_004569320.1 (463860..485656)

NW_025422127.1Genomic Context describing neighboring genes Neighboring gene RNA transcription, translation and transport factor protein-like Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene premelanosome protein Neighboring gene cyclin dependent kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De-novo transcriptome sequencing of a normalized cDNA pool from influenza infected ferrets. Camp JV, et al. PLoS One, 2012. PMID 22606336, Free PMC Article
  2. Sequencing, annotation, and characterization of the influenza ferret infectome. León AJ, et al. J Virol, 2013 Feb. PMID 23236062, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mustela putorius furo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1176430v1.1 Primary Assembly

Genomic

  1. NW_025422127.1 Reference ASM1176430v1.1 Primary Assembly

    Range
    1474217..1495932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004773061.3 → XP_004773118.1  diacylglycerol kinase alpha isoform X3

    See identical proteins and their annotated locations for XP_004773118.1

    UniProtKB/TrEMBL
    A0A8U0N9R8
    Conserved Domains (5) summary
    smart00045
    Location:518 → 699
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:376 → 497
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:112 → 181
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:204 → 252
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 108
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. XM_004773062.3 → XP_004773119.1  diacylglycerol kinase alpha isoform X3

    See identical proteins and their annotated locations for XP_004773119.1

    UniProtKB/TrEMBL
    A0A8U0N9R8
    Conserved Domains (5) summary
    smart00045
    Location:518 → 699
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:376 → 497
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:112 → 181
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:204 → 252
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 108
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. XM_004773060.3 → XP_004773117.1  diacylglycerol kinase alpha isoform X3

    See identical proteins and their annotated locations for XP_004773117.1

    UniProtKB/TrEMBL
    A0A8U0N9R8
    Conserved Domains (5) summary
    smart00045
    Location:518 → 699
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:376 → 497
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:112 → 181
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:204 → 252
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam14513
    Location:6 → 108
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  4. XM_013046162.2 → XP_012901616.1  diacylglycerol kinase alpha isoform X2

    UniProtKB/TrEMBL
    M3XPC9
    Related
    ENSMPUP00000000929.1
    Conserved Domains (7) summary
    smart00045
    Location:561 → 742
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:419 → 540
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:419 → 764
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:155 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:247 → 295
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:156 → 220
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:49 → 151
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. XM_045071539.1 → XP_044927474.1  diacylglycerol kinase alpha isoform X4

    UniProtKB/TrEMBL
    A0A8U0UUK2, M1EM31
    Conserved Domains (4) summary
    smart00109
    Location:272 → 319
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00046
    Location:444 → 565
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00051
    Location:180 → 249
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl00040
    Location:334 → 378
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  6. XM_004773057.3 → XP_004773114.1  diacylglycerol kinase alpha isoform X1

    UniProtKB/TrEMBL
    A0A8U0N9U5
    Conserved Domains (7) summary
    smart00045
    Location:586 → 767
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:444 → 565
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:444 → 789
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:180 → 249
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:272 → 320
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:181 → 245
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:74 → 176
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  7. XM_013046163.1 → XP_012901617.1  diacylglycerol kinase alpha isoform X5

    UniProtKB/TrEMBL
    A0A8U0NKW9
    Conserved Domains (5) summary
    smart00045
    Location:379 → 560
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:237 → 358
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20890
    Location:129 → 190
    C1_DGKalpha_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase alpha (DAG kinase alpha) and similar proteins
    cl00040
    Location:60 → 120
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl08302
    Location:1 → 42
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. XR_006604243.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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