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JAK2 Janus kinase 2 [ Echinops telfairi (small Madagascar hedgehog) ]

Gene ID: 101659376, updated on 20-Sep-2024

Summary

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Gene symbol
JAK2
Gene description
Janus kinase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Echinops telfairi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tenrecidae; Tenrecinae; Echinops
Orthologs
human mouse all
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Genomic context

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See JAK2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
103 current ASM31398v2 (GCF_000313985.2) Unplaced Scaffold NW_022103922.1 (6861387..6929069)
101 previous assembly EchTel2.0 (GCF_000313985.1) Unplaced Scaffold NW_004558790.1 (6861404..6928457)

NW_022103922.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 3 Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene nucleoside diphosphate kinase B-like Neighboring gene insulin like 6 Neighboring gene plasminogen receptor with a C-terminal lysine

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Echinops telfairi Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM31398v2 Primary Assembly

Genomic

  1. NW_022103922.1 Reference ASM31398v2 Primary Assembly

    Range
    6861387..6929069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004714459.2 → XP_004714516.1  tyrosine-protein kinase JAK2 isoform X1

    Conserved Domains (6) summary
    cd10379
    Location:386 → 482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  2. XM_030885335.2 → XP_030741195.1  tyrosine-protein kinase JAK2 isoform X2

Nucleotide Protein
Heading Accession and Version

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