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LRP6 LDL receptor related protein 6 [ Echinops telfairi (small Madagascar hedgehog) ]

Gene ID: 101638974, updated on 20-Sep-2024

Summary

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Gene symbol
LRP6
Gene description
LDL receptor related protein 6
Gene type
protein coding
RefSeq status
MODEL
Organism
Echinops telfairi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Tenrecidae; Tenrecinae; Echinops
Orthologs
human mouse all
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Genomic context

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See LRP6 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
103 current ASM31398v2 (GCF_000313985.2) Unplaced Scaffold NW_022105855.1 (2404615..2573435)
101 previous assembly EchTel2.0 (GCF_000313985.1) Unplaced Scaffold NW_004558819.1 (879147..1043491, complement)

NW_022105855.1Genomic Context describing neighboring genes Neighboring gene MANSC domain containing 1 Neighboring gene 60S ribosomal protein L17-like Neighboring gene cyclin-dependent kinases regulatory subunit 1-like Neighboring gene BCL2 like 14 Neighboring gene aspartate aminotransferase, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Wnt receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis involved in cholesterol transport IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Echinops telfairi Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM31398v2 Primary Assembly

Genomic

  1. NW_022105855.1 Reference ASM31398v2 Primary Assembly

    Range
    2404615..2573435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004716210.2 → XP_004716267.1  low-density lipoprotein receptor-related protein 6

    Conserved Domains (4) summary
    smart00135
    Location:397 → 437
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00112
    Location:1327 → 1361
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:150 → 190
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:592 → 627
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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