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CAPN3 calpain 3 [ Sorex araneus (European shrew) ]

Gene ID: 101558331, updated on 8-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
EnsemblRapid:ENSSARG00000035273
Gene type
protein coding
RefSeq status
MODEL
Organism
Sorex araneus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; Soricinae; Sorex
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_04 current mSorAra2.pri (GCF_027595985.1) 3 NC_073304.1 (87657718..87701511)
101 previous assembly SorAra2.0 (GCF_000181275.1) Unplaced Scaffold NW_004545893.1 (15206528..15250917)

Chromosome 3 - NC_073304.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 87A Neighboring gene glucosidase alpha, neutral C Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027595985.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSorAra2.pri

Genomic

  1. NC_073304.1 Reference mSorAra2.pri

    Range
    87657718..87701511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004609595.2 → XP_004609652.1  calpain-3

    Related
    ENSSARP00000014549.1, ENSSART00000044162.1
    Conserved Domains (6) summary
    cd00051
    Location:690 → 744
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 412
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:426 → 576
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:721 → 777
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:580 → 646
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:721 → 810
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version

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