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CAPN3 calpain 3 [ Ochotona princeps (American pika) ]

Gene ID: 101533222, updated on 8-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
Gene type
protein coding
RefSeq status
MODEL
Organism
Ochotona princeps
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Ochotonidae; Ochotona
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_07 current mOchPri1.hap1 (GCF_030435755.1) 6 NC_080837.1 (36095548..36137167, complement)
102 previous assembly OchPri4.0 (GCF_014633375.1) 17 NC_050552.1 (55827996..55869484)

Chromosome 6 - NC_080837.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene zinc finger protein 106 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030435755.1-RS_2023_07

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOchPri1.hap1

Genomic

  1. NC_080837.1 Reference mOchPri1.hap1

    Range
    36095548..36137167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004578147.2 → XP_004578204.1  calpain-3 isoform X4

    Conserved Domains (5) summary
    cd00051
    Location:605 → 659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381 → 531
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:636 → 692
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:636 → 725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_004578145.2 → XP_004578202.1  calpain-3 isoform X3

    Conserved Domains (6) summary
    cd00051
    Location:696 → 750
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:727 → 783
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 652
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:727 → 816
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_004578148.2 → XP_004578205.1  calpain-3 isoform X5

    Conserved Domains (5) summary
    cd00051
    Location:585 → 639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361 → 511
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:616 → 672
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:616 → 705
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_058666002.1 → XP_058521985.1  calpain-3 isoform X1

  5. XM_058666003.1 → XP_058521986.1  calpain-3 isoform X2

Nucleotide Protein
Heading Accession and Version

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