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CDH17 cadherin 17 [ Homo sapiens (human) ]

Gene ID: 1015, updated on 11-Apr-2024

Summary

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Official Symbol
CDH17provided by HGNC
Official Full Name
cadherin 17provided by HGNC
Primary source
HGNC:HGNC:1756
See related
Ensembl:ENSG00000079112 MIM:603017; AllianceGenome:HGNC:1756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPT1; CDH16; HPT-1
Summary
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Expression
Biased expression in duodenum (RPKM 145.2), small intestine (RPKM 127.8) and 2 other tissues See more
Orthologs
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Genomic context

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See CDH17 in Genome Data Viewer
Location:
8q22.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94127162..94217278, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (95252073..95342140, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95139390..95229506, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19363 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:94982395-94982896 Neighboring gene ribosomal protein L34 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27623 Neighboring gene Sharpr-MPRA regulatory region 136 Neighboring gene uncharacterized LOC124901979 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:95036583-95037782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27625 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:95073181-95073744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27626 Neighboring gene uncharacterized LOC105375647 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:95218310-95219509 Neighboring gene ribosomal protein L6 pseudogene 23 Neighboring gene uncharacterized LOC105375648 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95246124-95246703 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:95246704-95247282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:95247283-95247861 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:95272504-95272647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19365 Neighboring gene GTP binding protein overexpressed in skeletal muscle

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene. Yui A, et al. Sci Rep, 2023 Apr 20. PMID 37081068, Free PMC Article
  2. Mechanism of dimerization and structural features of human LI-cadherin. Yui A, et al. J Biol Chem, 2021 Sep. PMID 34364873, Free PMC Article
  3. Clinical correlation of cadherin-17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma. Zheng BH, et al. J Surg Oncol, 2021 Apr. PMID 33524213
  4. Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. Tian X, et al. Biomed Pharmacother, 2018 Dec. PMID 30227326
  5. Downregulation of liver-intestine cadherin enhances cisplatin-induced apoptosis in human gastric cancer BGC823 cells. Liu M, et al. Cancer Gene Ther, 2018 Feb. PMID 29203930

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene.
    Title: Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene.
  2. The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population.
    Title: The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population.
  3. CDH17+/CDX2+ Can be Helpful in Providing Support for Small Intestinal Origin Versus Pancreatic or Biliary Origin.
    Title: CDH17+/CDX2+ Can be Helpful in Providing Support for Small Intestinal Origin Versus Pancreatic or Biliary Origin.
  4. Mechanism of dimerization and structural features of human LI-cadherin.
    Title: Mechanism of dimerization and structural features of human LI-cadherin.
  5. A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.
    Title: A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.
  6. Clinical correlation of cadherin-17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma.
    Title: Clinical correlation of cadherin-17 marker with advanced tumor stages and poor prognosis of cholangiocarcinoma.
  7. Combined use of LI-cadherin and CDX2 can improve the accuracy in the diagnosis of metastatic adenocarcinoma cells in serous cavity effusion and provide some bases of histologic origin because of their high sensitivity and specificity.
    Title: LI-cadherin and CDX2: Useful Markers in Metastatic Gastrointestinal Adenocarcinoma Cells in Serous Cavity Effusion.
  8. immunophenotyping with CLDN18, CDH17, and PAX8 might improve the diagnostic accuracy of histopathological classifications of endocervical adenocarcinoma
    Title: Immunophenotype analysis using CLDN18, CDH17, and PAX8 for the subcategorization of endocervical adenocarcinomas in situ: gastric-type, intestinal-type, gastrointestinal-type, and Müllerian-type.
  9. CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways.
    Title: Disruption of oncogenic liver-intestine cadherin (CDH17) drives apoptotic pancreatic cancer death.
  10. CDH17 silencing induced apoptosis and inhibited autophagy in KM12SM and KM12C cells, and this autophagy protected the cells from apoptotic cell death.
    Title: Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26931, MGC138218, MGC142024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proton-dependent oligopeptide secondary active transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germinal center B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in marginal zone B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligopeptide transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oligopeptide transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cadherin-17
Names
HPT-1 cadherin
LI cadherin
cadherin 17, LI cadherin (liver-intestine)
cadherin-16
human intestinal peptide-associated transporter HPT-1
human peptide transporter 1
intestinal peptide-associated transporter HPT-1
liver-intestine cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144663.2 → NP_001138135.1  cadherin-17 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK312873, AP003351, BF591263, U07969, X83228
    Consensus CDS
    CCDS6260.1
    UniProtKB/Swiss-Prot
    Q12864, Q15336, Q2M2E0
    Related
    ENSP00000401468.2, ENST00000450165.6
    Conserved Domains (3) summary
    cd11304
    Location:570 → 663
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:271 → 338
    CA; Cadherin repeats
    cl29226
    Location:681 → 765
    Cadherin; Cadherin domain

  2. NM_001413951.1 → NP_001400880.1  cadherin-17 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  3. NM_001413952.1 → NP_001400881.1  cadherin-17 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478
    UniProtKB/Swiss-Prot
    Q12864, Q15336, Q2M2E0

  4. NM_001413953.1 → NP_001400882.1  cadherin-17 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478
    UniProtKB/Swiss-Prot
    Q12864, Q15336, Q2M2E0

  5. NM_001413954.1 → NP_001400883.1  cadherin-17 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  6. NM_001413955.1 → NP_001400884.1  cadherin-17 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  7. NM_001413956.1 → NP_001400885.1  cadherin-17 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  8. NM_001413957.1 → NP_001400886.1  cadherin-17 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  9. NM_001413958.1 → NP_001400887.1  cadherin-17 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  10. NM_001413959.1 → NP_001400888.1  cadherin-17 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  11. NM_001413960.1 → NP_001400889.1  cadherin-17 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  12. NM_001413961.1 → NP_001400890.1  cadherin-17 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

  13. NM_004063.4 → NP_004054.3  cadherin-17 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004054.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP003351, BF591263, DB009107, U07969, X83228
    Consensus CDS
    CCDS6260.1
    UniProtKB/Swiss-Prot
    Q12864, Q15336, Q2M2E0
    Related
    ENSP00000027335.3, ENST00000027335.8
    Conserved Domains (3) summary
    cd11304
    Location:570 → 663
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:271 → 338
    CA; Cadherin repeats
    cl29226
    Location:681 → 765
    Cadherin; Cadherin domain

RNA

  1. NR_182224.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003351, AP003478

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    94127162..94217278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    95252073..95342140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12864.3 GenPept UniProtKB/Swiss-Prot:Q12864

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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