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fgfr2 fibroblast growth factor receptor 2 [ Maylandia zebra (zebra mbuna) ]

Gene ID: 101463957, updated on 8-Mar-2024

Summary

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Gene symbol
fgfr2
Gene description
fibroblast growth factor receptor 2
See related
Ensembl:ENSMZEG00005010727
Gene type
protein coding
RefSeq status
MODEL
Organism
Maylandia zebra
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex
Orthologs
zebrafish all
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Genomic context

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See fgfr2 in Genome Data Viewer
Location:
chromosome: LG13
Exon count:
19
Annotation release Status Assembly LG Location
104 current M_zebra_UMD2a (GCF_000238955.4) LG13 NC_036792.1 (23660961..23698398)
101 previous assembly MetZeb1.1 (GCF_000238955.1) Unplaced Scaffold NW_004531773.1 (1099831..1137319, complement)

Linkage Group LG13 - NC_036792.1Genomic Context describing neighboring genes Neighboring gene delta-1-pyrroline-5-carboxylate synthase Neighboring gene arginyltransferase 1 Neighboring gene WD repeat domain 11 Neighboring gene phospholipid phosphatase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Common developmental pathways link tooth shape to regeneration. Fraser GJ, et al. Dev Biol, 2013 May 15. PMID 23422830, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Maylandia zebra Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference M_zebra_UMD2a Primary Assembly

Genomic

  1. NC_036792.1 Reference M_zebra_UMD2a Primary Assembly

    Range
    23660961..23698398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014410002.3 → XP_014265488.1  fibroblast growth factor receptor 2 isoform X4

    UniProtKB/TrEMBL
    A0A3P9BWF8
    Related
    ENSMZEP00005014303.1, ENSMZET00005014782.1
    Conserved Domains (5) summary
    cd05101
    Location:466 → 778
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:387 → 417
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

  2. XM_014410001.3 → XP_014265487.1  fibroblast growth factor receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A3P9BWF8
    Conserved Domains (5) summary
    cd05101
    Location:468 → 780
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:387 → 417
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

  3. XM_014410000.3 → XP_014265486.1  fibroblast growth factor receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A3P9BWF8
    Conserved Domains (5) summary
    cd05101
    Location:468 → 780
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:389 → 419
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 379
    Ig; Immunoglobulin domain

  4. XM_012921460.4 → XP_012776914.1  fibroblast growth factor receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_012776914.1

    UniProtKB/TrEMBL
    A0A3P9BWB7, A0A3P9BWF8
    Related
    ENSMZEP00005014263.1, ENSMZET00005014739.1
    Conserved Domains (5) summary
    cd05101
    Location:470 → 782
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:389 → 419
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 379
    Ig; Immunoglobulin domain

  5. XM_004559681.5 → XP_004559738.1  fibroblast growth factor receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_004559738.1

    UniProtKB/TrEMBL
    A0A3P9BWB7, A0A3P9BWF8
    Conserved Domains (5) summary
    cd05101
    Location:470 → 782
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:389 → 419
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 379
    Ig; Immunoglobulin domain

  6. XM_014410003.3 → XP_014265489.1  fibroblast growth factor receptor 2 isoform X5

    UniProtKB/TrEMBL
    A0A3P9BWF8, A0A3P9BWL4
    Related
    ENSMZEP00005014279.1, ENSMZET00005014755.1
    Conserved Domains (5) summary
    cd05101
    Location:384 → 696
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:303 → 333
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:189 → 192
    Ig; Ig strand A [structural motif]
    cd05857
    Location:87 → 181
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:189 → 293
    Ig; Immunoglobulin domain

  7. XM_014410004.3 → XP_014265490.1  fibroblast growth factor receptor 2 isoform X6

    UniProtKB/TrEMBL
    A0A3P9BWF8, A0A3P9BWQ4
    Related
    ENSMZEP00005014287.1, ENSMZET00005014765.1
    Conserved Domains (5) summary
    cd05101
    Location:359 → 671
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:278 → 308
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:164 → 167
    Ig; Ig strand A [structural motif]
    cd05857
    Location:62 → 156
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:164 → 268
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version

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