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CAPN3 calpain 3 [ Odobenus rosmarus divergens (Pacific walrus) ]

Gene ID: 101384331, updated on 8-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
Gene type
protein coding
RefSeq status
MODEL
Organism
Odobenus rosmarus divergens (sub-species: divergens)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Odobenidae; Odobenus
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
25
Annotation release Status Assembly Chr Location
101 current Oros_1.0 (GCF_000321225.1) Unplaced Scaffold NW_004450379.1 (422869..472359, complement)

NW_004450379.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene zinc finger protein 106 Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004450379.1 Unplaced Scaffold Reference Oros_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Odobenus rosmarus divergens Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Oros_1.0 Primary Assembly

Genomic

  1. NW_004450379.1 Reference Oros_1.0 Primary Assembly

    Range
    422869..472359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004400390.1 → XP_004400447.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A2U3VY62, A0A9B0GJV4
    Conserved Domains (5) summary
    cd00051
    Location:605 → 659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381 → 531
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:636 → 692
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:636 → 725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_004400388.1 → XP_004400445.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A2U3VY76, A0A9B0GJV4
    Conserved Domains (6) summary
    cd00051
    Location:691 → 745
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:722 → 778
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:647 → 716
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_004400387.1 → XP_004400444.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A2U3VY00, A0A9B0GJV4
    Conserved Domains (6) summary
    cd00051
    Location:697 → 751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:728 → 784
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:653 → 722
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_004400391.1 → XP_004400448.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A2U3VY39, A0A9B0GJV4
    Conserved Domains (5) summary
    cd00051
    Location:585 → 639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361 → 511
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:616 → 672
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:541 → 610
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version

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