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CAPN3 calpain 3 [ Trichechus manatus latirostris (Florida manatee) ]

Gene ID: 101356561, updated on 8-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
EnsemblRapid:ENSTMLG00000007320
Gene type
protein coding
RefSeq status
MODEL
Organism
Trichechus manatus latirostris (sub-species: latirostris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_01 current TriManLat1.0 (GCF_000243295.1) Unplaced Scaffold NW_004444012.1 (10661005..10714534)

NW_004444012.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 87A Neighboring gene glucosidase alpha, neutral C Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23 Neighboring gene leucine rich repeat containing 57

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004444012 Unplaced Scaffold Reference TriManLat1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of calpain complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000243295.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TriManLat1.0 Primary Assembly

Genomic

  1. NW_004444012.1 Reference TriManLat1.0 Primary Assembly

    Range
    10661005..10714534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004380664.2 → XP_004380721.1  calpain-3 isoform X9

    UniProtKB/TrEMBL
    A0A2Y9DTF5
    Related
    ENSTMLP00000010199.1, ENSTMLT00000010988.1
    Conserved Domains (5) summary
    cd00051
    Location:689 → 743
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:584 → 644
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:656 → 713
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_023735163.1 → XP_023590931.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9RBT1
    Conserved Domains (3) summary
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:610 → 777
    EFh_PEF_CAPN3; Calcium-activated neutral

  3. XM_004380666.2 → XP_004380723.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9DUP0
    Related
    ENSTMLP00000010232.1, ENSTMLT00000011023.1
    Conserved Domains (4) summary
    cd00051
    Location:605 → 659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381 → 531
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:636 → 725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_023735164.1 → XP_023590932.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9R8Z3
    Conserved Domains (3) summary
    pfam00648
    Location:77 → 339
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:360 → 503
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:534 → 701
    EFh_PEF_CAPN3; Calcium-activated neutral

  5. XM_023735165.1 → XP_023590933.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9RH93
    Conserved Domains (3) summary
    pfam00648
    Location:77 → 266
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:287 → 430
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:461 → 628
    EFh_PEF_CAPN3; Calcium-activated neutral

  6. XM_004380667.2 → XP_004380724.1  calpain-3 isoform X10

    UniProtKB/TrEMBL
    A0A2Y9DTE7
    Conserved Domains (4) summary
    cd00051
    Location:585 → 639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361 → 511
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:552 → 609
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_023735166.1 → XP_023590934.1  calpain-3 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9RG50
    Conserved Domains (3) summary
    pfam01067
    Location:209 → 352
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:383 → 550
    EFh_PEF_CAPN3; Calcium-activated neutral
    cl00051
    Location:1 → 188
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  8. XM_023735167.1 → XP_023590935.1  calpain-3 isoform X6

    UniProtKB/TrEMBL
    A0A2Y9R658
    Conserved Domains (3) summary
    pfam01067
    Location:72 → 215
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:246 → 413
    EFh_PEF_CAPN3; Calcium-activated neutral
    cl00051
    Location:15 → 61
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  9. XM_023735168.1 → XP_023590936.1  calpain-3 isoform X7

    UniProtKB/TrEMBL
    A0A2Y9RBT5
    Conserved Domains (3) summary
    pfam01067
    Location:60 → 203
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:234 → 401
    EFh_PEF_CAPN3; Calcium-activated neutral
    cl00051
    Location:3 → 49
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  10. XM_023735169.1 → XP_023590937.1  calpain-3 isoform X8

    UniProtKB/TrEMBL
    A0A2Y9R8Z7
    Conserved Domains (1) summary
    cd16190
    Location:43 → 210
    EFh_PEF_CAPN3; Calcium-activated neutral
Nucleotide Protein
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