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PTEN phosphatase and tensin homolog [ Orcinus orca (killer whale) ]

Gene ID: 101289838, updated on 8-Mar-2024

Summary

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Gene symbol
PTEN
Gene description
phosphatase and tensin homolog
See related
EnsemblRapid:ENSOORG00010010496
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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See PTEN in Genome Data Viewer
Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 14 NC_064572.1 (52794773..52881058)

Chromosome 14 - NC_064572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC117196426 Neighboring gene killin, p53 regulated DNA replication inhibitor Neighboring gene uncharacterized LOC117196445 Neighboring gene gastric triacylglycerol lipase Neighboring gene uncharacterized LOC117196429

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064572.1 Chromosome 14 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Liang H, et al. Cell Metab, 2014 May 6. PMID 24768297, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Names
mitochondrial PTENalpha
NP_001296406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309477.1 → NP_001296406.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    See identical proteins and their annotated locations for NP_001296406.1

    Status: PROVISIONAL

    Source sequence(s)
    BK008845
    UniProtKB/TrEMBL
    A0A024QYS4
    Related
    ENSOORP00010013124.1, ENSOORT00010015413.1
    Conserved Domains (2) summary
    smart00404
    Location:262 → 353
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    pfam10409
    Location:358 → 519
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064572.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    52794773..52881058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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