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PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Orcinus orca (killer whale) ]

Gene ID: 101278075, updated on 8-Mar-2024

Summary

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Gene symbol
PIK3CA
Gene description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
See related
EnsemblRapid:ENSOORG00010017554
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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See PIK3CA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 5 NC_064563.1 (61563899..61670133)

Chromosome 5 - NC_064563.1Genomic Context describing neighboring genes Neighboring gene tubulin polyglutamylase complex subunit 2-like Neighboring gene zinc finger matrin-type 3 Neighboring gene uncharacterized LOC117201610 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene uncharacterized LOC125964394 Neighboring gene protein CEBPZOS-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064563.1 Chromosome 5 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064563.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    61563899..61670133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004270521.4 → XP_004270569.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    See identical proteins and their annotated locations for XP_004270569.1

    Related
    ENSOORP00010023177.1, ENSOORT00010026317.1
    Conserved Domains (5) summary
    cd08398
    Location:325 → 484
    C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:173 → 292
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:525 → 696
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05175
    Location:695 → 1064
    PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
    pfam02192
    Location:32 → 107
    PI3K_p85B; PI3-kinase family, p85-binding domain

RNA

  1. XR_004483628.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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