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PKM pyruvate kinase M1/2 [ Orcinus orca (killer whale) ]

Gene ID: 101276272, updated on 8-Mar-2024

Summary

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Gene symbol
PKM
Gene description
pyruvate kinase M1/2
See related
EnsemblRapid:ENSOORG00010019795
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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See PKM in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 2 NC_064560.1 (87153933..87180772)

Chromosome 2 - NC_064560.1Genomic Context describing neighboring genes Neighboring gene CUGBP Elav-like family member 6 Neighboring gene uncharacterized LOC125963621 Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene GRAM domain containing 2A Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene myosin IXA Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064560.1 Chromosome 2 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pyruvate kinase PKM
Names
pyruvate kinase, muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064560.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    87153933..87180772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004276263.3 → XP_004276311.1  pyruvate kinase PKM isoform X1

    See identical proteins and their annotated locations for XP_004276311.1

    Related
    ENSOORP00010026222.1, ENSOORT00010029694.1
    Conserved Domains (1) summary
    cd00288
    Location:42 → 530
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  2. XM_033439997.2 → XP_033295888.1  pyruvate kinase PKM isoform X2

    Related
    ENSOORP00010026218.1, ENSOORT00010029690.1
    Conserved Domains (1) summary
    cd00288
    Location:42 → 530
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
Nucleotide Protein
Heading Accession and Version

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