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THPO thrombopoietin [ Orcinus orca (killer whale) ]

Gene ID: 101275544, updated on 8-Mar-2024

Summary

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Gene symbol
THPO
Gene description
thrombopoietin
See related
EnsemblRapid:ENSOORG00010016905
Gene type
protein coding
RefSeq status
MODEL
Organism
Orcinus orca
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
Orthologs
human mouse all
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Genomic context

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See THPO in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 5 NC_064563.1 (66390779..66395617, complement)

Chromosome 5 - NC_064563.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 131 member A Neighboring gene chloride voltage-gated channel 2 Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene chordin Neighboring gene 40S ribosomal protein S10-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064563.1 Chromosome 5 Reference mOrcOrc1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thrombopoietin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thrombopoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrcOrc1.1 Primary Assembly

Genomic

  1. NC_064563.1 Reference mOrcOrc1.1 Primary Assembly

    Range
    66390779..66395617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033403183.2 → XP_033259074.1  thrombopoietin isoform X2

    Related
    ENSOORP00010022148.1, ENSOORT00010025223.1
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 159
    EPO_TPO; Erythropoietin/thrombopoietin

  2. XM_033403181.2 → XP_033259072.1  thrombopoietin isoform X1

    Related
    ENSOORP00010022149.1, ENSOORT00010025224.1
    Conserved Domains (2) summary
    PHA03379
    Location:252 → 332
    PHA03379; EBNA-3A; Provisional
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin
Nucleotide Protein
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