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ARL4C ADP ribosylation factor like GTPase 4C [ Homo sapiens (human) ]

Gene ID: 10123, updated on 11-Apr-2024

Summary

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Official Symbol
ARL4Cprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 4Cprovided by HGNC
Primary source
HGNC:HGNC:698
See related
Ensembl:ENSG00000188042 MIM:604787; AllianceGenome:HGNC:698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAK; ARL7
Summary
ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 30.2), spleen (RPKM 30.0) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
2q37.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (234493041..234497081, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (234982177..234986217, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (235401685..235405725, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17354 Neighboring gene long intergenic non-protein coding RNA 1891 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:235405987-235406760 Neighboring gene CRISPRi-validated cis-regulatory element chr2.7113 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:235471377-235472120 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:235505034-235505574 Neighboring gene uncharacterized LOC105373936 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:235505575-235506115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:235512165-235513116 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:235531433-235532632 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:235549687-235550294 Neighboring gene NANOG hESC enhancer GRCh37_chr2:235570023-235570546 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:235596500-235597125 Neighboring gene Sharpr-MPRA regulatory region 2610 Neighboring gene long intergenic non-protein coding RNA 1173 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:235602982-235604181 Neighboring gene NANOG hESC enhancer GRCh37_chr2:235619073-235619654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer. Kanai R, et al. BMC Cancer, 2023 May 26. PMID 37237373, Free PMC Article
  2. ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jκ-H3K4Me3-OSBPL5. Yang J, et al. Hum Exp Toxicol, 2022 Jan-Dec. PMID 36366750
  3. RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation. Fujii S, et al. J Pathol, 2022 Jan. PMID 34622442
  4. ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments. Xie N, et al. J Cell Mol Med, 2021 Apr. PMID 33724652, Free PMC Article
  5. ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target. Kimura K, et al. Cancer Sci, 2020 Mar. PMID 31925985, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.
    Title: Stepwise activation of p63 and the MEK/ERK pathway induces the expression of ARL4C to promote oral squamous cell carcinoma cell proliferation.
  2. ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.
    Title: ARL4C is associated with epithelial-to-mesenchymal transition in colorectal cancer.
  3. ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jkappa-H3K4Me3-OSBPL5.
    Title: ARL4C depletion suppresses the resistance of ovarian cancer to carboplatin by disrupting cholesterol transport and autophagy via notch-RBP-Jκ-H3K4Me3-OSBPL5.
  4. Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.
    Title: Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.
  5. RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
    Title: RAF1-MEK/ERK pathway-dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation.
  6. ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.
    Title: ARL4C might serve as a prognostic factor and a novel therapeutic target for gastric cancer: bioinformatics analyses and biological experiments.
  7. High ARL4C expression is associated with Peritoneal Dissemination in Gastric Cancer.
    Title: ASO Author Reflections: ARL4C and Peritoneal Dissemination in Gastric Cancer.
  8. ARL4C is involved in the initiation of the premalignant stage.
    Title: ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.
  9. ARL4C antisense oligonucleotides (ASO) accumulated in cancer cells more efficiently than the surrounding normal cells in the liver and decreased ARL4C expression in the tumor. These results suggest that ARL4C ASO represents a novel targeted nucleic acid medicine for the treatment of primary and metastatic liver cancers.
    Title: Chemically Modified Antisense Oligonucleotide Against ARL4C Inhibits Primary and Metastatic Liver Tumor Growth.
  10. ARL4C stabilized by AKT/mTOR pathway promotes the invasiveness of PTEN-deficient glioblastoma cells.
    Title: ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN-deficient primary human glioblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog
Genome-wide association study of pancreatic cancer in Japanese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 4C
Names
ADP ribosylation factor-like protein 7
ADP-ribosylation factor-like 4C
ADP-ribosylation factor-like 7
ADP-ribosylation factor-like protein LAK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282431.2 → NP_001269360.1  ADP-ribosylation factor-like protein 4C isoform 1

    See identical proteins and their annotated locations for NP_001269360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC105145, AJ579850, BC089043
    Consensus CDS
    CCDS63169.1
    UniProtKB/Swiss-Prot
    P56559
    Related
    ENSP00000339754.3, ENST00000339728.6
    Conserved Domains (1) summary
    cd04152
    Location:11 → 192
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

  2. NM_005737.3 → NP_005728.2  ADP-ribosylation factor-like protein 4C isoform 2

    See identical proteins and their annotated locations for NP_005728.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional internal segment which results in alternate stop codon compared to variant 1. The encoded isoform (2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    BC001051, BM541491, BM904613, BU844902, CA413100, CD358707, Y17804
    Consensus CDS
    CCDS2512.1
    UniProtKB/Swiss-Prot
    P56559, Q4A519, Q53R10, Q9BVN1, Q9UQ34
    Related
    ENSP00000375057.2, ENST00000390645.2
    Conserved Domains (1) summary
    cd04152
    Location:11 → 192
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    234493041..234497081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    234982177..234986217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56559.1 GenPept UniProtKB/Swiss-Prot:P56559

Gene LinkOut

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