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ACTR1B actin related protein 1B [ Homo sapiens (human) ]

Gene ID: 10120, updated on 11-Apr-2024

Summary

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Official Symbol
ACTR1Bprovided by HGNC
Official Full Name
actin related protein 1Bprovided by HGNC
Primary source
HGNC:HGNC:168
See related
Ensembl:ENSG00000115073 MIM:605144; AllianceGenome:HGNC:168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC3; ARP1B; CTRN2
Summary
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in spleen (RPKM 24.2), brain (RPKM 24.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (97655939..97664044, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98114160..98122265, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (98272402..98280507, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98261483-98262417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:98278969-98279610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16241 Neighboring gene U4 spliceosomal RNA Neighboring gene UBTF like 6 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:98304422-98305621 Neighboring gene chromosome 2 open reading frame 92 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98307157-98307956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98323640-98324200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98324201-98324759 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:98327684-98327873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98329847-98330820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332052-98332567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98332568-98333082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98340736-98341326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98356023-98356522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11794 Neighboring gene zeta chain of T cell receptor associated protein kinase 70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16243 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16244 Neighboring gene transmembrane protein 131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. Weng YQ, et al. J Cancer Res Clin Oncol, 2008 Feb. PMID 17619203
  2. Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization. Elsea SH, et al. Cytogenet Cell Genet, 1999. PMID 10343100
  3. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. Clark SW, et al. Mol Biol Cell, 1994 Dec. PMID 7696711, Free PMC Article
  4. Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity. Appierto V, et al. Mol Cancer Ther, 2009 Dec. PMID 19996280
  5. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Hata A, et al. Genes Dev, 1998 Jan 15. PMID 9436979, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
    Title: Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.
  2. Down-regulation of beta-centractin is associated with hepatocellular carcinoma immune escape
    Title: Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in secretory granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
beta-centractin
Names
ARP1 actin related protein 1 homolog B
ARP1 actin-related protein 1 homolog B, centractin beta
centractin beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005735.4 → NP_005726.1  beta-centractin

    See identical proteins and their annotated locations for NP_005726.1

    Status: REVIEWED

    Source sequence(s)
    AC017099, BC010090, X82207
    Consensus CDS
    CCDS2033.1
    UniProtKB/Swiss-Prot
    D3DVH2, P42025, Q53SK5, Q9BRB7
    UniProtKB/TrEMBL
    Q13841
    Related
    ENSP00000289228.5, ENST00000289228.7
    Conserved Domains (1) summary
    cl17037
    Location:5 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    97655939..97664044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263854.6 → XP_005263911.1  beta-centractin isoform X1

    See identical proteins and their annotated locations for XP_005263911.1

    UniProtKB/TrEMBL
    Q13841
    Conserved Domains (1) summary
    cl17037
    Location:1 → 302
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_017003116.2 → XP_016858605.1  beta-centractin isoform X2

    UniProtKB/TrEMBL
    Q13841
    Conserved Domains (1) summary
    cl17037
    Location:2 → 332
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791765.1 Reference GRCh38.p14 PATCHES

    Range
    581970..590075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332905.1 → XP_054188880.1  beta-centractin isoform X1

  2. XM_054332906.1 → XP_054188881.1  beta-centractin isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    98114160..98122265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340086.1 → XP_054196061.1  beta-centractin isoform X1

  2. XM_054340087.1 → XP_054196062.1  beta-centractin isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42025.1 GenPept UniProtKB/Swiss-Prot:P42025

Gene LinkOut

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